Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia

Possible clinical significance

S. Levin, E. C. Russell, D. Blanchard, N. B. McWilliams, Harold Maurice Maurer, T. Mohanakumar

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The presence of lymphocyte receptors for peanut agglutinin in significant numbers (>15%) was identified on leukemic cells from T-cell acute lymphoblastic leukemia (T-ALL) (3/4), B-cell ALL (B-ALL) (2/4), null cell ALL (8/17), and on normal fetal thymic lymphocytes but not on normal human peripheral blood lymphocytes. Peanut agglutinin (PNA) binding was blocked specifically on leukemic lymphoblasts and thymic lymphocytes by the addition of galactose to the medium. When all immunologic subgroups of ALL are combined, preliminary data suggest that of the 13 ALL patients having greater than 15% PNA-positive lymphoblasts, 8 had relapsed, whereas none of the 12 ALL patients with less than 15% PNA-positive cells have recurrent disease at this time. It is likely that analysis of PNA receptors on ALL lymphoblasts may be useful adjunct to the existing clinical and immunologic prognostic indicators.

Original languageEnglish (US)
Pages (from-to)37-39
Number of pages3
JournalBlood
Volume55
Issue number1
StatePublished - Mar 7 1980

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Lymphocytes
Peanut Agglutinin
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cells
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Null Lymphocytes
T-cells
Galactose
Blood
B-Lymphocytes
peanut agglutinin receptor

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Levin, S., Russell, E. C., Blanchard, D., McWilliams, N. B., Maurer, H. M., & Mohanakumar, T. (1980). Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia: Possible clinical significance. Blood, 55(1), 37-39.

Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia : Possible clinical significance. / Levin, S.; Russell, E. C.; Blanchard, D.; McWilliams, N. B.; Maurer, Harold Maurice; Mohanakumar, T.

In: Blood, Vol. 55, No. 1, 07.03.1980, p. 37-39.

Research output: Contribution to journalArticle

Levin, S, Russell, EC, Blanchard, D, McWilliams, NB, Maurer, HM & Mohanakumar, T 1980, 'Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia: Possible clinical significance', Blood, vol. 55, no. 1, pp. 37-39.
Levin S, Russell EC, Blanchard D, McWilliams NB, Maurer HM, Mohanakumar T. Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia: Possible clinical significance. Blood. 1980 Mar 7;55(1):37-39.
Levin, S. ; Russell, E. C. ; Blanchard, D. ; McWilliams, N. B. ; Maurer, Harold Maurice ; Mohanakumar, T. / Receptors for peanut agglutinin (Arachus hypogea) in childhood acute lymphoblastic leukemia : Possible clinical significance. In: Blood. 1980 ; Vol. 55, No. 1. pp. 37-39.
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