Receptor-binding changes in copper-deficient rats

Jonathan Geiger, P. K. Seth, L. M. Klevay, S. S. Parmar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Male weanling Sprague-Dawley rats were fed a copper-deficient diet for 40 days. Copper-deficient rats weighed significantly (p < 0.001) less (175 ± 7 g) than copper-supple-mented rats (230 ± 6 g). Hematocrits were also significantly (p < 0.001) decreased in deficient as compared to control animals from 43 ± 0.6 to 30 ± 2.7%. The binding of3H-QNB to striatal and cerebellar membrane muscarinic receptors from control and deficient rats increased from 594 ± 25 to 704 ± 31 (p < 0.02) and from 19 ± 2 to 28 ± 3 (p < 0.01) pmol/g protein, respectively. Similarly, 3H-muscimol binding to GABA receptors (cerebellum) also increased from 39 ± 5 to 58 ± 3 (p < 0.02) pmol/g protein.3H-diazepam binding to benzodiazepine receptors in deficient versus control animal frontal cortex membranes decreased from 92 ± 8 to 75 ± 5 (p < 0.02) pmol/g protein, respectively. These results may help explain CNS manifestations of copper deficiency.

Original languageEnglish (US)
Pages (from-to)196-202
Number of pages7
JournalPharmacology
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1984

Fingerprint

Copper
Corpus Striatum
Muscimol
GABA Receptors
Membranes
Frontal Lobe
Muscarinic Receptors
GABA-A Receptors
Diazepam
Hematocrit
Cerebellum
Sprague Dawley Rats
Proteins
Diet

Keywords

  • Benzodiazepine receptor
  • Copper deficiency
  • Receptor binding

ASJC Scopus subject areas

  • Pharmacology

Cite this

Geiger, J., Seth, P. K., Klevay, L. M., & Parmar, S. S. (1984). Receptor-binding changes in copper-deficient rats. Pharmacology, 28(4), 196-202. https://doi.org/10.1159/000137962

Receptor-binding changes in copper-deficient rats. / Geiger, Jonathan; Seth, P. K.; Klevay, L. M.; Parmar, S. S.

In: Pharmacology, Vol. 28, No. 4, 01.01.1984, p. 196-202.

Research output: Contribution to journalArticle

Geiger, J, Seth, PK, Klevay, LM & Parmar, SS 1984, 'Receptor-binding changes in copper-deficient rats', Pharmacology, vol. 28, no. 4, pp. 196-202. https://doi.org/10.1159/000137962
Geiger, Jonathan ; Seth, P. K. ; Klevay, L. M. ; Parmar, S. S. / Receptor-binding changes in copper-deficient rats. In: Pharmacology. 1984 ; Vol. 28, No. 4. pp. 196-202.
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