Recent progress on tissue-resident adult stem cell biology and their therapeutic implications

Murielle Mimeault, Surinder Kumar Batra

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Recent progress in the field of the stem cell research has given new hopes to treat and even cure diverse degenerative disorders and incurable diseases in human. Particularly, the identification of a rare population of adult stem cells in the most tissues/organs in human has emerged as an attractive source of multipotent stem/progenitor cells for cell replacement-based therapies and tissue engineering in regenerative medicine. The tissue-resident adult stem/progenitor cells offer the possibility to stimulate their in vivo differentiation or to use their ex vivo expanded progenies for cell replacement-based therapies with multiple applications in human. Among the human diseases that could be treated by the stem cell-based therapies, there are hematopoietic and immune disorders, multiple degenerative disorders, such as Parkinson's and Alzeimeher's diseases, type 1 or 2 diabetes mellitus as well as eye, liver, lung, skin and cardiovascular disorders and aggressive and metastatic cancers. In addition, the genetically-modified adult stem/progenitor cells could also be used as delivery system for expressing the therapeutic molecules in specific damaged areas of different tissues. Recent advances in cancer stem/progenitor cell research also offer the possibility to targeting these undifferentiated and malignant cells that provide critical functions in cancer initiation and progression and disease relapse for treating the patients diagnosed with the advanced and metastatic cancers which remain incurable in the clinics with the current therapies.

Original languageEnglish (US)
Pages (from-to)27-49
Number of pages23
JournalStem Cell Reviews
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2008

Fingerprint

Adult Stem Cells
Cell Biology
Stem Cells
Stem Cell Research
Multipotent Stem Cells
Therapeutics
Neoplasms
Regenerative Medicine
Neoplastic Stem Cells
Immune System Diseases
Tissue Engineering
Cell- and Tissue-Based Therapy
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Parkinson Disease
Disease Progression
Recurrence
Lung
Skin
Liver

Keywords

  • Adult stem/progenitor cells
  • Cancer stem/progenitor cells
  • Gene therapy
  • Regenerative medicine
  • Targeted therapies

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. / Mimeault, Murielle; Batra, Surinder Kumar.

In: Stem Cell Reviews, Vol. 4, No. 1, 01.03.2008, p. 27-49.

Research output: Contribution to journalArticle

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