Recent developments in the pathophysiology of cholestasis

Grant F Hutchins, John L. Gollan

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

The past decade has brought tremendous growth in the understanding of the pathophysiologic mechanisms involved in cholestasis, both at the genetic and acquired levels. The discovery and characterization of an array of hepatobiliary transport proteins, the nuclear receptors that regulate them, and the potential clinical implications of these defective, altered, or variably expressed proteins are the key elements of our current understanding of cholestasis. It is hoped that future studies will enhance therapeutic options and the ability to care for patients with cholestatic disorders.

Original languageEnglish (US)
Pages (from-to)1-26
Number of pages26
JournalClinics in liver disease
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2004

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Cholestasis
Cytoplasmic and Nuclear Receptors
Patient Care
Carrier Proteins
Growth
Proteins
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Recent developments in the pathophysiology of cholestasis. / Hutchins, Grant F; Gollan, John L.

In: Clinics in liver disease, Vol. 8, No. 1, 01.02.2004, p. 1-26.

Research output: Contribution to journalReview article

Hutchins, Grant F ; Gollan, John L. / Recent developments in the pathophysiology of cholestasis. In: Clinics in liver disease. 2004 ; Vol. 8, No. 1. pp. 1-26.
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