Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies

Murielle Mimeault, Randall E. Brand, Aaron A. Sasson, Surinder Kumar Batra

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

This review describes the recent advances in the molecular events involved in pancreatic cancer initiation, progression, and metastasis. Additionally, the importance of deregulated cellular signaling elements as potential targets for developing novel therapeutic strategies against incurable forms of pancreatic cancer is reported. The emphasis is on the critical functions gained by numerous growth factors and their receptors, such as epidermal growth factor receptor, hedgehog signaling, and proangiogenic agents such as vascular endothelial factor and interleukin-8 for the sustained growth, survival, and metastasis of pancreatic cancer cells. The molecular mechanisms associated with antitumoral properties and the clinical benefits of gemcitabine alone or in combination with other cytotoxic agents for the treatment of pancreatic cancer are discussed.

Original languageEnglish (US)
Pages (from-to)301-316
Number of pages16
JournalPancreas
Volume31
Issue number4
DOIs
StatePublished - Nov 1 2005

Fingerprint

Pancreatic Neoplasms
gemcitabine
Neoplasm Metastasis
Growth Factor Receptors
Cytotoxins
Therapeutics
Interleukin-8
Epidermal Growth Factor Receptor
Growth

Keywords

  • Combination therapy
  • Diagnosis
  • Epidermal growth factor epidermal growth factor receptor system
  • Gemcitabine
  • Pancreas carcinogenesis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. / Mimeault, Murielle; Brand, Randall E.; Sasson, Aaron A.; Batra, Surinder Kumar.

In: Pancreas, Vol. 31, No. 4, 01.11.2005, p. 301-316.

Research output: Contribution to journalReview article

Mimeault, Murielle ; Brand, Randall E. ; Sasson, Aaron A. ; Batra, Surinder Kumar. / Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapies. In: Pancreas. 2005 ; Vol. 31, No. 4. pp. 301-316.
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