Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies

Murielle Mimeault, Surinder Kumar Batra

Research output: Contribution to journalReview article

130 Citations (Scopus)

Abstract

Recent advances on differently-expressed gene products and their functions during the progression from localized androgen-dependent states into androgen-independent and metastatic forms of prostate cancer are reported. The expression levels of numerous oncogenes and tumor suppressor genes in distinct prostatic cancer epithelial cell lines and tissues relative to normal prostate cells are described. This is carried out to identify the signaling elements that are altered during the initiation, progression and metastatic process of prostate cancer. Additional information on the interactions between certain deregulated signaling pathways such as androgen receptor (AR), estrogen receptors, epidermal growth factor receptor (EGFR), hedgehog and Wnt/β-catenin cascades in controlling the proliferation, survival and invasion of tumor prostate epithelial cells during the disease progression is described. The emphasis is on the critical functions of the AR and EGF-EGFR systems at all stages during prostate carcinogenesis. Of therapeutic interest, new strategies for the diagnosis and treatment of localized and metastatic forms of prostate cancer by targeting multiple tumorigenic signaling elements are also reported.

Original languageEnglish (US)
Pages (from-to)1-22
Number of pages22
JournalCarcinogenesis
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2006

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Prostatic Neoplasms
Prostate
Androgen Receptors
Epidermal Growth Factor Receptor
Androgens
Epithelial Cells
Catenins
Therapeutics
Tumor Suppressor Genes
Oncogenes
Epidermal Growth Factor
Estrogen Receptors
Disease Progression
Carcinogenesis
Epithelium
Cell Line
Genes
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies. / Mimeault, Murielle; Batra, Surinder Kumar.

In: Carcinogenesis, Vol. 27, No. 1, 01.01.2006, p. 1-22.

Research output: Contribution to journalReview article

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