Real-time perfusion echocardiography during treadmill exercise and dobutamine stress testing

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Real-time perfusion (RTP) echocardiographic imaging with a continuous infusion of microbubbles has improved the sensitivity of dobutamine stress echocardiography (DSE) in detecting coronary artery disease (CAD). The impact of RTP on treadmill exercise stress echocardiography (TESE) is unclear. Design: Retrospective database review. Setting/patients/interventions: RTP was utilised in 254 DSE and TESE patients being examined for the presence of significant CAD. A continuous infusion of 3% Definity (Lantheus Medical Imaging) was used for all studies, and contrast replenishment (MCR), plateau intensity (PMCE) and wall motion (WM) were examined for the detection of CAD. Main outcome measures: Sensitivity/specificity/accuracy to detect CAD. Results: For DSE, the sensitivity of myocardial perfusion (MP) imaging with RTP was 85%, which was significantly higher than WM analysis (72%; p<0.05). The improvement in sensitivity with MP analysis during DSE was primarily the result of better detection of left anterior descending disease. MP sensitivity during TESE was significantly better than MP sensitivity during DSE (98% versus 85%; p<0.05), and WM sensitivity during TESE was better than WM sensitivity during DSE (89% versus 72%; p<0.05). The improvement in WM sensitivity during TESE was due to detection of subendocardial wall thickening abnormalities in 48% of the patients with induced subendocardial perfusion defects. Conclusion: Myocardial perfusion imaging with RTP improves the detection of CAD during both DSE and TESE. During TESE, the subendocardial perfusion defects improve WM sensitivity by delineating subendocardial WM abnormalities.

Original languageEnglish (US)
Pages (from-to)220-225
Number of pages6
JournalHeart
Volume96
Issue number3
DOIs
StatePublished - Feb 1 2010

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Stress Echocardiography
Dobutamine
Echocardiography
Perfusion
Exercise
Coronary Artery Disease
Myocardial Perfusion Imaging
Microbubbles
Perfusion Imaging
Diagnostic Imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Real-time perfusion echocardiography during treadmill exercise and dobutamine stress testing. / Dodla, S.; Xie, Feng; Smith, M.; O'Leary, Edward Lewis; Porter, Thomas Richard.

In: Heart, Vol. 96, No. 3, 01.02.2010, p. 220-225.

Research output: Contribution to journalArticle

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abstract = "Background: Real-time perfusion (RTP) echocardiographic imaging with a continuous infusion of microbubbles has improved the sensitivity of dobutamine stress echocardiography (DSE) in detecting coronary artery disease (CAD). The impact of RTP on treadmill exercise stress echocardiography (TESE) is unclear. Design: Retrospective database review. Setting/patients/interventions: RTP was utilised in 254 DSE and TESE patients being examined for the presence of significant CAD. A continuous infusion of 3{\%} Definity (Lantheus Medical Imaging) was used for all studies, and contrast replenishment (MCR), plateau intensity (PMCE) and wall motion (WM) were examined for the detection of CAD. Main outcome measures: Sensitivity/specificity/accuracy to detect CAD. Results: For DSE, the sensitivity of myocardial perfusion (MP) imaging with RTP was 85{\%}, which was significantly higher than WM analysis (72{\%}; p<0.05). The improvement in sensitivity with MP analysis during DSE was primarily the result of better detection of left anterior descending disease. MP sensitivity during TESE was significantly better than MP sensitivity during DSE (98{\%} versus 85{\%}; p<0.05), and WM sensitivity during TESE was better than WM sensitivity during DSE (89{\%} versus 72{\%}; p<0.05). The improvement in WM sensitivity during TESE was due to detection of subendocardial wall thickening abnormalities in 48{\%} of the patients with induced subendocardial perfusion defects. Conclusion: Myocardial perfusion imaging with RTP improves the detection of CAD during both DSE and TESE. During TESE, the subendocardial perfusion defects improve WM sensitivity by delineating subendocardial WM abnormalities.",
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AU - Xie, Feng

AU - Smith, M.

AU - O'Leary, Edward Lewis

AU - Porter, Thomas Richard

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N2 - Background: Real-time perfusion (RTP) echocardiographic imaging with a continuous infusion of microbubbles has improved the sensitivity of dobutamine stress echocardiography (DSE) in detecting coronary artery disease (CAD). The impact of RTP on treadmill exercise stress echocardiography (TESE) is unclear. Design: Retrospective database review. Setting/patients/interventions: RTP was utilised in 254 DSE and TESE patients being examined for the presence of significant CAD. A continuous infusion of 3% Definity (Lantheus Medical Imaging) was used for all studies, and contrast replenishment (MCR), plateau intensity (PMCE) and wall motion (WM) were examined for the detection of CAD. Main outcome measures: Sensitivity/specificity/accuracy to detect CAD. Results: For DSE, the sensitivity of myocardial perfusion (MP) imaging with RTP was 85%, which was significantly higher than WM analysis (72%; p<0.05). The improvement in sensitivity with MP analysis during DSE was primarily the result of better detection of left anterior descending disease. MP sensitivity during TESE was significantly better than MP sensitivity during DSE (98% versus 85%; p<0.05), and WM sensitivity during TESE was better than WM sensitivity during DSE (89% versus 72%; p<0.05). The improvement in WM sensitivity during TESE was due to detection of subendocardial wall thickening abnormalities in 48% of the patients with induced subendocardial perfusion defects. Conclusion: Myocardial perfusion imaging with RTP improves the detection of CAD during both DSE and TESE. During TESE, the subendocardial perfusion defects improve WM sensitivity by delineating subendocardial WM abnormalities.

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