Real-time monitoring of cardiovascular function in rhesus macaques infected with zaire ebolavirus

Mark G. Kortepeter, James V. Lawler, Anna Honko, Mike Bray, Joshua C. Johnson, Bret K. Purcell, Gene G. Olinger, Robert Rivard, Matthew J. Hepburn, Lisa E. Hensley

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Nine rhesus macaques were implanted with multisensor telemetry devices and internal jugular vein catheters before being infected with Zaire ebolavirus. All animals developed viremia, fever, a hemorrhagic rash, and typical changes of Ebola hemorrhagic fever in clinical laboratory tests. Three macaques unexpectedly survived this usually lethal disease, making it possible to compare physiological parameters in lethally challenged animals and survivors. After the onset of fever, lethal illness was characterized by a decline in mean arterial blood pressure, an increase in pulse and respiratory rate, lactic acidosis, and renal failure. Survivors showed less pronounced change in these parameters. Four macaques were randomized to receive supplemental volumes of intravenous normal saline when they became hypotensive. Although those animals had less severe renal compromise, no apparent survival benefit was observed. This is the first report of continuous physiologic monitoring in filovirus-infected nonhuman primates and the first to attempt cardiovascular support with intravenous fluids.

Original languageEnglish (US)
Pages (from-to)S1000-S1010
JournalJournal of Infectious Diseases
Volume204
Issue numberSUPPL. 3
DOIs
StatePublished - Nov 1 2011

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Ebolavirus
Democratic Republic of the Congo
Macaca mulatta
Macaca
Ebola Hemorrhagic Fever
Arterial Pressure
Fever
Lactic Acidosis
Telemetry
Viremia
Jugular Veins
Physiologic Monitoring
Respiratory Rate
Exanthema
Primates
Renal Insufficiency
Catheters
Heart Rate
Kidney
Equipment and Supplies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Real-time monitoring of cardiovascular function in rhesus macaques infected with zaire ebolavirus. / Kortepeter, Mark G.; Lawler, James V.; Honko, Anna; Bray, Mike; Johnson, Joshua C.; Purcell, Bret K.; Olinger, Gene G.; Rivard, Robert; Hepburn, Matthew J.; Hensley, Lisa E.

In: Journal of Infectious Diseases, Vol. 204, No. SUPPL. 3, 01.11.2011, p. S1000-S1010.

Research output: Contribution to journalArticle

Kortepeter, MG, Lawler, JV, Honko, A, Bray, M, Johnson, JC, Purcell, BK, Olinger, GG, Rivard, R, Hepburn, MJ & Hensley, LE 2011, 'Real-time monitoring of cardiovascular function in rhesus macaques infected with zaire ebolavirus', Journal of Infectious Diseases, vol. 204, no. SUPPL. 3, pp. S1000-S1010. https://doi.org/10.1093/infdis/jir337
Kortepeter, Mark G. ; Lawler, James V. ; Honko, Anna ; Bray, Mike ; Johnson, Joshua C. ; Purcell, Bret K. ; Olinger, Gene G. ; Rivard, Robert ; Hepburn, Matthew J. ; Hensley, Lisa E. / Real-time monitoring of cardiovascular function in rhesus macaques infected with zaire ebolavirus. In: Journal of Infectious Diseases. 2011 ; Vol. 204, No. SUPPL. 3. pp. S1000-S1010.
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