Real supermodels wear wool

Summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming

Kristin A. Beede, Sean W. Limesand, Jessica L Petersen, Dustin T Yates

Research output: Contribution to journalArticle

Abstract

Implications • Intrauterine growth restriction (IUGR) continues to be a global epidemic that is associated with high early-life mortality rates and greater risk for developing metabolic disorders that lower length and quality of life in affected individuals. • Fetal programming of muscle growth and metabolic function associated with IUGR is often comparable among nonlitter bearing mammalian species, which allows much of the information learned in domestic animal models to be applicable to humans (and other animals). • Recent studies in sheep models of IUGR have begun to uncover the molecular mechanisms linking adaptive fetal programming and metabolic dysfunction. • Targets of adaptive fetal programming indicated by sheep studies include adrenergic and inflammatory pathways that regulate skeletal muscle growth and glucose metabolism. Adaptive changes in these pathways represent potential focus areas for prenatal interventions or postnatal treatments to improve outcomes in IUGR-born offspring.

Original languageEnglish (US)
Pages (from-to)34-43
Number of pages10
JournalAnimal Frontiers
Volume9
Issue number3
DOIs
StatePublished - Jan 1 2019

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Wool
Fetal Development
wool
Sheep
Animal Models
animal models
sheep
metabolic diseases
Growth
quality of life
domestic animals
skeletal muscle
muscles
glucose
metabolism
animals
Domestic Animals
Adrenergic Agents
Skeletal Muscle
Quality of Life

Keywords

  • DOHaD
  • Developmental origins
  • Fetal stress
  • Intrauterine growth restriction
  • Placental insufficiency

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

Cite this

Real supermodels wear wool : Summarizing the impact of the pregnant sheep as an animal model for adaptive fetal programming. / Beede, Kristin A.; Limesand, Sean W.; Petersen, Jessica L; Yates, Dustin T.

In: Animal Frontiers, Vol. 9, No. 3, 01.01.2019, p. 34-43.

Research output: Contribution to journalArticle

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