Reactive oxygen species in chronic obstructive pulmonary disease

Samia Boukhenouna, Mark A. Wilson, Karim Bahmed, Beata Kosmider

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative stress and is the main factor of COPD development. Cigarette smoke also contributes to the imbalance of oxidant/antioxidant due to exogenous reactive oxygen species (ROS). Moreover, endogenously released ROS during the inflammatory process and mitochondrial dysfunction may contribute to this disease progression. ROS and reactive nitrogen species (RNS) can oxidize different biomolecules such as DNA, proteins, and lipids leading to epithelial cell injury and death. Various detoxifying enzymes and antioxidant defense systems can be involved in ROS removal. In this review, we summarize the main findings regarding the biological role of ROS, which may contribute to COPD development, and cytoprotective mechanisms against this disease progression.

Original languageEnglish (US)
Article number5730395
JournalOxidative medicine and cellular longevity
Volume2018
DOIs
StatePublished - Jan 1 2018

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Pulmonary diseases
Chronic Obstructive Pulmonary Disease
Reactive Oxygen Species
Tobacco Products
Disease Progression
Antioxidants
Reactive Nitrogen Species
Oxidative stress
Chronic Bronchitis
Environmental Exposure
Emphysema
Biomolecules
Oxidants
Smoke
Oxidative Stress
Cell Death
Smoking
Epithelial Cells
Lipids
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Cell Biology

Cite this

Reactive oxygen species in chronic obstructive pulmonary disease. / Boukhenouna, Samia; Wilson, Mark A.; Bahmed, Karim; Kosmider, Beata.

In: Oxidative medicine and cellular longevity, Vol. 2018, 5730395, 01.01.2018.

Research output: Contribution to journalReview article

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