Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation

Janos Sumegi, Jack Spira, Hervé Bazin, Josiane Szpirer, Göran Levan, George Klein

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Abstract

Two B-cell-derived tumours, human Burkitt's lymphoma (BL) and murine plasmacytoma (MPC), are regularly associated with a distinctive form of chromosomal translocation (for reviews see refs 1, 2). In BL, the distal portion of chromosome 8 breaks off and is transposed, in most cases, to chromosome 14, known to carry the immunoglobulin heavy-chain locus3. In about 5% of the cases the same distal part of the chromosome 8 has moved to either chromosome 2 or 22, to the neighbourhood of the κ or the λ locus, respectively4,5. In MFC the distal region of chromosome 15 is transposed to the chromosome 12, known to carry the immunoglobulin heavy-chain locus6, or enters into reciprocal exchange with the κ locus-carrying chromosome 6 (ref. 7). Several laboratories have located c-myc, the cellular homologue of the MC29 retro viral oncogene v-myc, to human chromosome 8 (refs 8-10) and mouse chromosome 15 (refs 11-13). It has also been shown that the BL- and MFC-associated translocations remove the c-myc gene from its original site and transpose it into or close to one of the immunoglobulin gene clusters8,14-16. In view of the above findings we also looked for possible involvement of the c-myc gene in a B-cell-derived tumour of a third species, the rat. Rat immunocytomas of spontaneous origin carry a reciprocal translocation between chromosomes 6 and 7 (ref. 17). Here we have localized the c-myc locus to chromosome 7 of the rat. Moreover, we have found that the c-myc gene was rearranged in four of five immunocytomas carrying the characteristic chromosomal translocation.

Original languageEnglish (US)
Pages (from-to)497-498
Number of pages2
JournalNature
Volume306
Issue number5942
DOIs
StatePublished - Dec 1 1983

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Genetic Translocation
myc Genes
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 8
Burkitt Lymphoma
Chromosomes, Human, Pair 15
Immunoglobulin Heavy Chains
Chromosomes, Human, Pair 6
B-Lymphocytes
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 22
Chromosome Breakage
Chromosomes, Human, Pair 12
Immunoglobulin Genes
Plasmacytoma
Chromosomes, Human, Pair 2
Human Chromosomes
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Sumegi, J., Spira, J., Bazin, H., Szpirer, J., Levan, G., & Klein, G. (1983). Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. Nature, 306(5942), 497-498. https://doi.org/10.1038/306497a0

Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. / Sumegi, Janos; Spira, Jack; Bazin, Hervé; Szpirer, Josiane; Levan, Göran; Klein, George.

In: Nature, Vol. 306, No. 5942, 01.12.1983, p. 497-498.

Research output: Contribution to journalArticle

Sumegi, J, Spira, J, Bazin, H, Szpirer, J, Levan, G & Klein, G 1983, 'Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation', Nature, vol. 306, no. 5942, pp. 497-498. https://doi.org/10.1038/306497a0
Sumegi, Janos ; Spira, Jack ; Bazin, Hervé ; Szpirer, Josiane ; Levan, Göran ; Klein, George. / Rat c-myc oncogene is located on chromosome 7 and rearranges in immunocytomas with t(6:7) chromosomal translocation. In: Nature. 1983 ; Vol. 306, No. 5942. pp. 497-498.
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abstract = "Two B-cell-derived tumours, human Burkitt's lymphoma (BL) and murine plasmacytoma (MPC), are regularly associated with a distinctive form of chromosomal translocation (for reviews see refs 1, 2). In BL, the distal portion of chromosome 8 breaks off and is transposed, in most cases, to chromosome 14, known to carry the immunoglobulin heavy-chain locus3. In about 5{\%} of the cases the same distal part of the chromosome 8 has moved to either chromosome 2 or 22, to the neighbourhood of the κ or the λ locus, respectively4,5. In MFC the distal region of chromosome 15 is transposed to the chromosome 12, known to carry the immunoglobulin heavy-chain locus6, or enters into reciprocal exchange with the κ locus-carrying chromosome 6 (ref. 7). Several laboratories have located c-myc, the cellular homologue of the MC29 retro viral oncogene v-myc, to human chromosome 8 (refs 8-10) and mouse chromosome 15 (refs 11-13). It has also been shown that the BL- and MFC-associated translocations remove the c-myc gene from its original site and transpose it into or close to one of the immunoglobulin gene clusters8,14-16. In view of the above findings we also looked for possible involvement of the c-myc gene in a B-cell-derived tumour of a third species, the rat. Rat immunocytomas of spontaneous origin carry a reciprocal translocation between chromosomes 6 and 7 (ref. 17). Here we have localized the c-myc locus to chromosome 7 of the rat. Moreover, we have found that the c-myc gene was rearranged in four of five immunocytomas carrying the characteristic chromosomal translocation.",
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