Rapid rates of lineage-specific gene duplication and deletion in the α-globin gene family

Federico G. Hoffmann, Juan C. Opazo, Jay F. Storz

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Phylogeny reconstructions of the globin gene families have revealed that paralogous genes within species are often more similar to one another than they are to their orthologous counterparts in closely related species. This pattern has been previously attributed to mechanisms of concerted evolution such as interparalog gene conversion that homogenize sequence variation between tandemly duplicated genes and therefore create the appearance of recent common ancestry. Here we report a comparative genomic analysis of the α-globin gene family in mammals that reveal a surprisingly high rate of lineage-specific gene duplication and deletion via unequal crossing-over. Results of our analysis reveal that patterns of sequence similarity between paralogous α-like globin genes from the same species are only partly explained by concerted evolution between preexisting gene duplicates. In a number of cases, sequence similarity between paralogous sequences from the same species is attributable to recent ancestry between the products of de novo gene duplications. As a result of this surprisingly rapid rate of gene gain and loss, many mammals possess α-like globin genes that have no orthologous counterparts in closely related species. The resultant variation in gene copy number among species may represent an important source of regulatory variation that affects physiologically important aspects of blood oxygen transport and aerobic energy metabolism.

Original languageEnglish (US)
Pages (from-to)591-602
Number of pages12
JournalMolecular biology and evolution
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2008

Fingerprint

Gene Duplication
Globins
gene deletion
Gene Deletion
gene duplication
Genes
gene
genes
concerted evolution
Mammals
ancestry
Duplicate Genes
mammals
gene dosage
duplicate genes
Gene Conversion
gene conversion
Gene Dosage
crossing over
Phylogeny

Keywords

  • Birth-and-death evolution
  • Concerted evolution
  • Gene duplication
  • Gene family
  • Hemoglobin
  • α-globin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

Rapid rates of lineage-specific gene duplication and deletion in the α-globin gene family. / Hoffmann, Federico G.; Opazo, Juan C.; Storz, Jay F.

In: Molecular biology and evolution, Vol. 25, No. 3, 01.03.2008, p. 591-602.

Research output: Contribution to journalArticle

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