Rapid onset metastatic pulmonary calcifications in end-stage renal disease

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Metastatic calcifi cation occurs in patients on long-term dialysis. Electrolyte imbalances in these individuals can result in calcium deposition into otherwise normal tissues. In this article, we present the unusual case of a patient who progressed to end-stage renal disease soon after a liver transplant and developed extensive pulmonary metastatic calcifi cations within a few months of starting dialysis. A 56-year-old female underwent an orthotopic liver transplant for end-stage liver disease secondary to hepatitis C; her immunosuppression included tacrolimus and prednisone. She developed acute kidney injury in the immediate post-operative period, which progressed to end-stage renal disease. Her serum calcium and phosphorus levels were within normal limits. Within a few months, a CT scan of her chest showed progressive development of metastatic pulmonary calcifi cation. A CTguided right lung biopsy showed extensive calcifi cation in the alveolar and blood vessel walls with fi broblastic plugs in the alveolar spaces. To our knowledge, this is the fi rst report of metastatic pulmonary calcifi cation developing rapidly after initiation of hemodialysis. Immunosuppressive therapy may have played a role in the development of metastatic calcifi cation.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalDialysis and Transplantation
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Chronic Kidney Failure
Cations
Lung
Dialysis
Calcium
Transplants
End Stage Liver Disease
Liver
Tacrolimus
Immunosuppressive Agents
Hepatitis C
Prednisone
Acute Kidney Injury
Immunosuppression
Phosphorus
Electrolytes
Blood Vessels
Renal Dialysis
Thorax
Biopsy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Rapid onset metastatic pulmonary calcifications in end-stage renal disease. / Tendulkar, Ketki K; Lazenby, Audrey J; Groggel, Gerald C.

In: Dialysis and Transplantation, Vol. 39, No. 3, 01.03.2010, p. 109-111.

Research output: Contribution to journalArticle

@article{e343e975e2534a71bba994a5d813e705,
title = "Rapid onset metastatic pulmonary calcifications in end-stage renal disease",
abstract = "Metastatic calcifi cation occurs in patients on long-term dialysis. Electrolyte imbalances in these individuals can result in calcium deposition into otherwise normal tissues. In this article, we present the unusual case of a patient who progressed to end-stage renal disease soon after a liver transplant and developed extensive pulmonary metastatic calcifi cations within a few months of starting dialysis. A 56-year-old female underwent an orthotopic liver transplant for end-stage liver disease secondary to hepatitis C; her immunosuppression included tacrolimus and prednisone. She developed acute kidney injury in the immediate post-operative period, which progressed to end-stage renal disease. Her serum calcium and phosphorus levels were within normal limits. Within a few months, a CT scan of her chest showed progressive development of metastatic pulmonary calcifi cation. A CTguided right lung biopsy showed extensive calcifi cation in the alveolar and blood vessel walls with fi broblastic plugs in the alveolar spaces. To our knowledge, this is the fi rst report of metastatic pulmonary calcifi cation developing rapidly after initiation of hemodialysis. Immunosuppressive therapy may have played a role in the development of metastatic calcifi cation.",
author = "Tendulkar, {Ketki K} and Lazenby, {Audrey J} and Groggel, {Gerald C.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1002/dat.20404",
language = "English (US)",
volume = "39",
pages = "109--111",
journal = "Dialysis and Transplantation",
issn = "0090-2934",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Rapid onset metastatic pulmonary calcifications in end-stage renal disease

AU - Tendulkar, Ketki K

AU - Lazenby, Audrey J

AU - Groggel, Gerald C.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Metastatic calcifi cation occurs in patients on long-term dialysis. Electrolyte imbalances in these individuals can result in calcium deposition into otherwise normal tissues. In this article, we present the unusual case of a patient who progressed to end-stage renal disease soon after a liver transplant and developed extensive pulmonary metastatic calcifi cations within a few months of starting dialysis. A 56-year-old female underwent an orthotopic liver transplant for end-stage liver disease secondary to hepatitis C; her immunosuppression included tacrolimus and prednisone. She developed acute kidney injury in the immediate post-operative period, which progressed to end-stage renal disease. Her serum calcium and phosphorus levels were within normal limits. Within a few months, a CT scan of her chest showed progressive development of metastatic pulmonary calcifi cation. A CTguided right lung biopsy showed extensive calcifi cation in the alveolar and blood vessel walls with fi broblastic plugs in the alveolar spaces. To our knowledge, this is the fi rst report of metastatic pulmonary calcifi cation developing rapidly after initiation of hemodialysis. Immunosuppressive therapy may have played a role in the development of metastatic calcifi cation.

AB - Metastatic calcifi cation occurs in patients on long-term dialysis. Electrolyte imbalances in these individuals can result in calcium deposition into otherwise normal tissues. In this article, we present the unusual case of a patient who progressed to end-stage renal disease soon after a liver transplant and developed extensive pulmonary metastatic calcifi cations within a few months of starting dialysis. A 56-year-old female underwent an orthotopic liver transplant for end-stage liver disease secondary to hepatitis C; her immunosuppression included tacrolimus and prednisone. She developed acute kidney injury in the immediate post-operative period, which progressed to end-stage renal disease. Her serum calcium and phosphorus levels were within normal limits. Within a few months, a CT scan of her chest showed progressive development of metastatic pulmonary calcifi cation. A CTguided right lung biopsy showed extensive calcifi cation in the alveolar and blood vessel walls with fi broblastic plugs in the alveolar spaces. To our knowledge, this is the fi rst report of metastatic pulmonary calcifi cation developing rapidly after initiation of hemodialysis. Immunosuppressive therapy may have played a role in the development of metastatic calcifi cation.

UR - http://www.scopus.com/inward/record.url?scp=77950687905&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950687905&partnerID=8YFLogxK

U2 - 10.1002/dat.20404

DO - 10.1002/dat.20404

M3 - Article

VL - 39

SP - 109

EP - 111

JO - Dialysis and Transplantation

JF - Dialysis and Transplantation

SN - 0090-2934

IS - 3

ER -