Rapid Communication: A cis‐Acting Element, Tα‐1, in the Upstream Region of Rod α‐Transducin Gene that Binds a Developmentally Regulated Retina‐Specific Nuclear Factor

Iqbal Ahmad, Xiu Yu, Colin J. Barnstable

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Abstract: The G protein transducin (T) is an integral component of the signal transduction pathway in photoreceptors. We have identified a cis‐acting element, Ta‐1, in the upstream region of the mouse rod a‐T (T) gene that may be important for tissue‐specific expression. Tα‐1 binds a retina‐specific nuclear factor of apparent molecular mass of 90 kDa. Binding to the Tα‐1 site is developmentally regulated and peaks between postnatal days 6 and 9. This corresponds to the time of rod photoreceptor maturation and the rise in T gene expression. The sequence of Tα‐1 shows homology with RET‐1, a cis‐acting element in the proximal promoter of opsin gene that binds a distinct retina‐specific factor. Tα‐1 and RET‐1 sequences may have been derived from a prototype Tα‐1/RET‐1 sequence, evolved to confer photoreceptor specificity on retina‐specific genes.

Original languageEnglish (US)
Pages (from-to)396-399
Number of pages4
JournalJournal of Neurochemistry
Volume62
Issue number1
DOIs
StatePublished - Jan 1994

Fingerprint

Transducin
Genes
Communication
Opsins
Retinal Rod Photoreceptor Cells
Signal transduction
Molecular mass
GTP-Binding Proteins
Gene expression
Signal Transduction
Gene Expression

Keywords

  • G protein
  • Photoreceptor.

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

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title = "Rapid Communication: A cis‐Acting Element, Tα‐1, in the Upstream Region of Rod α‐Transducin Gene that Binds a Developmentally Regulated Retina‐Specific Nuclear Factor",
abstract = "Abstract: The G protein transducin (T) is an integral component of the signal transduction pathway in photoreceptors. We have identified a cis‐acting element, Ta‐1, in the upstream region of the mouse rod a‐T (Trα) gene that may be important for tissue‐specific expression. Tα‐1 binds a retina‐specific nuclear factor of apparent molecular mass of 90 kDa. Binding to the Tα‐1 site is developmentally regulated and peaks between postnatal days 6 and 9. This corresponds to the time of rod photoreceptor maturation and the rise in Trα gene expression. The sequence of Tα‐1 shows homology with RET‐1, a cis‐acting element in the proximal promoter of opsin gene that binds a distinct retina‐specific factor. Tα‐1 and RET‐1 sequences may have been derived from a prototype Tα‐1/RET‐1 sequence, evolved to confer photoreceptor specificity on retina‐specific genes.",
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author = "Iqbal Ahmad and Xiu Yu and Barnstable, {Colin J.}",
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T2 - A cis‐Acting Element, Tα‐1, in the Upstream Region of Rod α‐Transducin Gene that Binds a Developmentally Regulated Retina‐Specific Nuclear Factor

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N2 - Abstract: The G protein transducin (T) is an integral component of the signal transduction pathway in photoreceptors. We have identified a cis‐acting element, Ta‐1, in the upstream region of the mouse rod a‐T (Trα) gene that may be important for tissue‐specific expression. Tα‐1 binds a retina‐specific nuclear factor of apparent molecular mass of 90 kDa. Binding to the Tα‐1 site is developmentally regulated and peaks between postnatal days 6 and 9. This corresponds to the time of rod photoreceptor maturation and the rise in Trα gene expression. The sequence of Tα‐1 shows homology with RET‐1, a cis‐acting element in the proximal promoter of opsin gene that binds a distinct retina‐specific factor. Tα‐1 and RET‐1 sequences may have been derived from a prototype Tα‐1/RET‐1 sequence, evolved to confer photoreceptor specificity on retina‐specific genes.

AB - Abstract: The G protein transducin (T) is an integral component of the signal transduction pathway in photoreceptors. We have identified a cis‐acting element, Ta‐1, in the upstream region of the mouse rod a‐T (Trα) gene that may be important for tissue‐specific expression. Tα‐1 binds a retina‐specific nuclear factor of apparent molecular mass of 90 kDa. Binding to the Tα‐1 site is developmentally regulated and peaks between postnatal days 6 and 9. This corresponds to the time of rod photoreceptor maturation and the rise in Trα gene expression. The sequence of Tα‐1 shows homology with RET‐1, a cis‐acting element in the proximal promoter of opsin gene that binds a distinct retina‐specific factor. Tα‐1 and RET‐1 sequences may have been derived from a prototype Tα‐1/RET‐1 sequence, evolved to confer photoreceptor specificity on retina‐specific genes.

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