Raising intestinal contents viscosity leads to greater excretion of neutral steroids but not bile acids in hamsters and rats

Timothy P Carr, Kimberly J. Wood, Craig A. Hassel, Rajan Bahl, Daniel D. Gallaher

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

To examine the effect of intestinal contents viscosity on fecal steroid excretion independent of colonic fermentation, hamsters and rats were fed cholesterol-containing diets containing either cellulose or different viscosity grades of hydroxypropyl methylcellulose (HPMC), a non-fermentable fiber, as the dietary fiber source. HPMC feeding relative to cellulose significantly lowered plasma cholesterol in hamsters and liver cholesterol in rats. Fecal neutral steroid excretion was significantly greater in both species consuming HPMC compared to cellulose. Fecal bile acid excretion was not altered in hamsters, but was reduced in rats fed HPMC compared to cellulose. Thus, greater intestinal contents supernatant viscosity results in reduced plasma (hamster) or liver (rat) cholesterol and greater neutral steroid excretion, whereas bile acid excretion is unaffected or reduced. This suggests that viscosity is the principal characteristic of dietary fiber responsible for cholesterol lowering, and that this effect is due to increased excretion of cholesterol from the body.

Original languageEnglish (US)
Pages (from-to)91-102
Number of pages12
JournalNutrition Research
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

Gastrointestinal Contents
Bile Acids and Salts
Viscosity
Cricetinae
Steroids
Cholesterol
Cellulose
Dietary Fiber
Liver
Fermentation
Diet
Hypromellose Derivatives

Keywords

  • Bile acids
  • Cholesterol
  • Dietary fiber
  • Hamsters
  • Hydroxypropyl methylcellulose
  • Rats

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Raising intestinal contents viscosity leads to greater excretion of neutral steroids but not bile acids in hamsters and rats. / Carr, Timothy P; Wood, Kimberly J.; Hassel, Craig A.; Bahl, Rajan; Gallaher, Daniel D.

In: Nutrition Research, Vol. 23, No. 1, 01.01.2003, p. 91-102.

Research output: Contribution to journalArticle

Carr, Timothy P ; Wood, Kimberly J. ; Hassel, Craig A. ; Bahl, Rajan ; Gallaher, Daniel D. / Raising intestinal contents viscosity leads to greater excretion of neutral steroids but not bile acids in hamsters and rats. In: Nutrition Research. 2003 ; Vol. 23, No. 1. pp. 91-102.
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