A rapid, simple and inexpensive synthesis of 5‐radiohalogenated‐2′‐deoxyuridine from 5‐trimethylstannyl‐2′‐deoxyuridine is described. The total reaction and purification time including thin layer chromatography (tlc) for quality control is less than 30 min. This method produces excellent yields (>95%) of 123I‐, 125I‐, 131I‐UdR. The radiochemical purity of all tested preparations (>20) was determined to be greater than 99%. This new method is the basis of a radiolabeling kit/generator for preparation of radiohalogenated nucleosides. 2′‐Deoxyuridine (UdR) halogenated with a stable isotope of bromine was also synthesized indicating that the method can be applied to the preparation of 5‐radiobromo‐2′‐deoxyuridine (BUdR).
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - Jun 1994|