Radioiododemercuration: a simple synthesis of 5-[ 123/125/127 I]iodo-2′-deoxyuridine

Janina Baranowska-Kortylewicz, Berma M. Kinsey, Warren W. Layne, Amin I. Kassis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Through the use of iododemercuration, 5-[ 123/125 I]iodo-2′-deoxyuridine was synthesized rapidly and with high radiochemical purity from 5-chloromercuri-2′-deoxyuridine. The synthesis of radioiodinated 2′-deoxyuridine was achieved in one step in the presence of Iodogen in 50% yield after isolation by reverse phase high performance column chromatography. The radiochemical purity was greater than 99%. The ease and rapidity of both preparation and isolation of no-carrier-added 5-[ 123/125 I]iodo-2′-deoxyuridine, as well as the absence of any starting material, suggests that radiohalodemercuration may be the method of choice for this and structurally similar compounds.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalInternational Journal of Radiation Applications and Instrumentation. Part
Volume39
Issue number4
DOIs
StatePublished - 1988
Externally publishedYes

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Column chromatography
isolation
purity
chromatography
synthesis
preparation

ASJC Scopus subject areas

  • Radiation
  • Engineering(all)

Cite this

Radioiododemercuration : a simple synthesis of 5-[ 123/125/127 I]iodo-2′-deoxyuridine. / Baranowska-Kortylewicz, Janina; Kinsey, Berma M.; Layne, Warren W.; Kassis, Amin I.

In: International Journal of Radiation Applications and Instrumentation. Part, Vol. 39, No. 4, 1988, p. 335-341.

Research output: Contribution to journalArticle

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