Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications

Jingwei Xie, Matthew R. MacEwan, Wilson Z. Ray, Wenying Liu, Daku Y. Siewe, Younan Xia

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

This paper reports the fabrication of scaffolds consisting of radially aligned poly(ε-caprolactone) nanofibers by utilizing a collector composed of a central point electrode and a peripheral ring electrode. This novel class of scaffolds was able to present nanoscale topographic cues to cultured cells, directing and enhancing their migration from the periphery to the center. We also established that such scaffolds could induce faster cellular migration and population than nonwoven mats consisting of random nanofibers. Dural fibroblast cells cultured on these two types of scaffolds were found to express type I collagen, the main extracellular matrix component in dural mater. The type I collagen exhibited a high degree of organization on the scaffolds of radially aligned fibers and a haphazard distribution on the scaffolds of random fibers. Taken together, the scaffolds based on radially aligned, electrospun nanofibers show great potential as artificial dural substitutes and may be particularly useful as biomedical patches or grafts to induce wound closure and/or tissue regeneration.

Original languageEnglish (US)
Pages (from-to)5027-5036
Number of pages10
JournalACS Nano
Volume4
Issue number9
DOIs
StatePublished - Sep 28 2010

Fingerprint

Tissue regeneration
collagens
Nanofibers
regeneration
cultured cells
Scaffolds
closures
substitutes
fibers
electrodes
cues
fibroblasts
accumulators
Collagen
fabrication
Collagen Type I
rings
matrices
Cells
Electrodes

Keywords

  • aligned nanofibers
  • dural substitutes
  • electrospinning
  • wound closure

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications. / Xie, Jingwei; MacEwan, Matthew R.; Ray, Wilson Z.; Liu, Wenying; Siewe, Daku Y.; Xia, Younan.

In: ACS Nano, Vol. 4, No. 9, 28.09.2010, p. 5027-5036.

Research output: Contribution to journalArticle

Xie, Jingwei ; MacEwan, Matthew R. ; Ray, Wilson Z. ; Liu, Wenying ; Siewe, Daku Y. ; Xia, Younan. / Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications. In: ACS Nano. 2010 ; Vol. 4, No. 9. pp. 5027-5036.
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