Race affects outcome among infants with intestinal failure

Robert H. Squires, Jane Balint, Simon Horslen, Paul W. Wales, Jason Soden, Christopher Duggan, Ruosha Li, Steven H. Belle, Cartland Burns, George Mazariegos, Anita Nucci, Jane Anne Yaworski, Danielle Sebbens, Rhonda Cunningham, Daniel Kamin, Tom Jaksic, Hueng Bae Kim, Sharon Collier, Melanie Connolly, Daniel H. Teitelbaum & 50 others Pamela Brown, Michele Johnson, Robert Drongowski, Christina Valentine, Steven Teich, Beth Skaggs, Robert Venick, Martin G. Martin, Patty Beckwith, James Dunn, Douglas G. Farmer, Laurie Reyen, Susan Rhee, Diana Farmer, Sang Mo Kang, Lane Bower, Debra Sudan, David F Mercer, Dean L. Antonson, Stephen C Raynor, Brandy Sunderman, Kris Seipel, J. Andres Martinez, Brent Polk, Martha Ballew, Beth A. Carter, Mary Brandt, Saul Karpen, Sara Philips, Kristin Brown, Alejandro De La Torre, Sara Fidanza, Frances Malone, Patrick Healey, Jorge Reyes, Cheryl Davis, Jeffrey A. Rudolph, Samuel Kocoshis, Greg Tiao, Jacqueline Wessel, Riccardo Superina, Valeria Cohran, Kimberley Kazmerski, Lisa Keys, Margaret Richard, David Sigalet, Conrad Cole, Sharon Lawlor, Tamara Haller, Marcia Kurs-Lasky

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF.

Methods: This was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into ''white'' and ''nonwhite'' children.

Results: Of 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P< 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P=0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center.

Conclusions: Race is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF. Key Words: intestinal failure, intestinal transplant, outcome, race.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalJournal of pediatric gastroenterology and nutrition
Volume59
Issue number4
DOIs
StatePublished - Oct 8 2014

Fingerprint

Transplants
Incidence
Parenteral Nutrition
Low Birth Weight Infant
Multicenter Studies
Medical Records
Cohort Studies
Transplantation
Regression Analysis
Pediatrics
Morbidity
Survival
Mortality

Keywords

  • Intestinal failure
  • Intestinal transplant
  • Outcome
  • Race

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

Cite this

Squires, R. H., Balint, J., Horslen, S., Wales, P. W., Soden, J., Duggan, C., ... Kurs-Lasky, M. (2014). Race affects outcome among infants with intestinal failure. Journal of pediatric gastroenterology and nutrition, 59(4), 537-543. https://doi.org/10.1097/MPG.0000000000000456

Race affects outcome among infants with intestinal failure. / Squires, Robert H.; Balint, Jane; Horslen, Simon; Wales, Paul W.; Soden, Jason; Duggan, Christopher; Li, Ruosha; Belle, Steven H.; Burns, Cartland; Mazariegos, George; Nucci, Anita; Yaworski, Jane Anne; Sebbens, Danielle; Cunningham, Rhonda; Kamin, Daniel; Jaksic, Tom; Kim, Hueng Bae; Collier, Sharon; Connolly, Melanie; Teitelbaum, Daniel H.; Brown, Pamela; Johnson, Michele; Drongowski, Robert; Valentine, Christina; Teich, Steven; Skaggs, Beth; Venick, Robert; Martin, Martin G.; Beckwith, Patty; Dunn, James; Farmer, Douglas G.; Reyen, Laurie; Rhee, Susan; Farmer, Diana; Kang, Sang Mo; Bower, Lane; Sudan, Debra; Mercer, David F; Antonson, Dean L.; Raynor, Stephen C; Sunderman, Brandy; Seipel, Kris; Martinez, J. Andres; Polk, Brent; Ballew, Martha; Carter, Beth A.; Brandt, Mary; Karpen, Saul; Philips, Sara; Brown, Kristin; De La Torre, Alejandro; Fidanza, Sara; Malone, Frances; Healey, Patrick; Reyes, Jorge; Davis, Cheryl; Rudolph, Jeffrey A.; Kocoshis, Samuel; Tiao, Greg; Wessel, Jacqueline; Superina, Riccardo; Cohran, Valeria; Kazmerski, Kimberley; Keys, Lisa; Richard, Margaret; Sigalet, David; Cole, Conrad; Lawlor, Sharon; Haller, Tamara; Kurs-Lasky, Marcia.

In: Journal of pediatric gastroenterology and nutrition, Vol. 59, No. 4, 08.10.2014, p. 537-543.

Research output: Contribution to journalArticle

Squires, RH, Balint, J, Horslen, S, Wales, PW, Soden, J, Duggan, C, Li, R, Belle, SH, Burns, C, Mazariegos, G, Nucci, A, Yaworski, JA, Sebbens, D, Cunningham, R, Kamin, D, Jaksic, T, Kim, HB, Collier, S, Connolly, M, Teitelbaum, DH, Brown, P, Johnson, M, Drongowski, R, Valentine, C, Teich, S, Skaggs, B, Venick, R, Martin, MG, Beckwith, P, Dunn, J, Farmer, DG, Reyen, L, Rhee, S, Farmer, D, Kang, SM, Bower, L, Sudan, D, Mercer, DF, Antonson, DL, Raynor, SC, Sunderman, B, Seipel, K, Martinez, JA, Polk, B, Ballew, M, Carter, BA, Brandt, M, Karpen, S, Philips, S, Brown, K, De La Torre, A, Fidanza, S, Malone, F, Healey, P, Reyes, J, Davis, C, Rudolph, JA, Kocoshis, S, Tiao, G, Wessel, J, Superina, R, Cohran, V, Kazmerski, K, Keys, L, Richard, M, Sigalet, D, Cole, C, Lawlor, S, Haller, T & Kurs-Lasky, M 2014, 'Race affects outcome among infants with intestinal failure', Journal of pediatric gastroenterology and nutrition, vol. 59, no. 4, pp. 537-543. https://doi.org/10.1097/MPG.0000000000000456
Squires, Robert H. ; Balint, Jane ; Horslen, Simon ; Wales, Paul W. ; Soden, Jason ; Duggan, Christopher ; Li, Ruosha ; Belle, Steven H. ; Burns, Cartland ; Mazariegos, George ; Nucci, Anita ; Yaworski, Jane Anne ; Sebbens, Danielle ; Cunningham, Rhonda ; Kamin, Daniel ; Jaksic, Tom ; Kim, Hueng Bae ; Collier, Sharon ; Connolly, Melanie ; Teitelbaum, Daniel H. ; Brown, Pamela ; Johnson, Michele ; Drongowski, Robert ; Valentine, Christina ; Teich, Steven ; Skaggs, Beth ; Venick, Robert ; Martin, Martin G. ; Beckwith, Patty ; Dunn, James ; Farmer, Douglas G. ; Reyen, Laurie ; Rhee, Susan ; Farmer, Diana ; Kang, Sang Mo ; Bower, Lane ; Sudan, Debra ; Mercer, David F ; Antonson, Dean L. ; Raynor, Stephen C ; Sunderman, Brandy ; Seipel, Kris ; Martinez, J. Andres ; Polk, Brent ; Ballew, Martha ; Carter, Beth A. ; Brandt, Mary ; Karpen, Saul ; Philips, Sara ; Brown, Kristin ; De La Torre, Alejandro ; Fidanza, Sara ; Malone, Frances ; Healey, Patrick ; Reyes, Jorge ; Davis, Cheryl ; Rudolph, Jeffrey A. ; Kocoshis, Samuel ; Tiao, Greg ; Wessel, Jacqueline ; Superina, Riccardo ; Cohran, Valeria ; Kazmerski, Kimberley ; Keys, Lisa ; Richard, Margaret ; Sigalet, David ; Cole, Conrad ; Lawlor, Sharon ; Haller, Tamara ; Kurs-Lasky, Marcia. / Race affects outcome among infants with intestinal failure. In: Journal of pediatric gastroenterology and nutrition. 2014 ; Vol. 59, No. 4. pp. 537-543.
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abstract = "Objective: Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF.Methods: This was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into ''white'' and ''nonwhite'' children.Results: Of 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P< 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P=0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center.Conclusions: Race is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF. Key Words: intestinal failure, intestinal transplant, outcome, race.",
keywords = "Intestinal failure, Intestinal transplant, Outcome, Race",
author = "Squires, {Robert H.} and Jane Balint and Simon Horslen and Wales, {Paul W.} and Jason Soden and Christopher Duggan and Ruosha Li and Belle, {Steven H.} and Cartland Burns and George Mazariegos and Anita Nucci and Yaworski, {Jane Anne} and Danielle Sebbens and Rhonda Cunningham and Daniel Kamin and Tom Jaksic and Kim, {Hueng Bae} and Sharon Collier and Melanie Connolly and Teitelbaum, {Daniel H.} and Pamela Brown and Michele Johnson and Robert Drongowski and Christina Valentine and Steven Teich and Beth Skaggs and Robert Venick and Martin, {Martin G.} and Patty Beckwith and James Dunn and Farmer, {Douglas G.} and Laurie Reyen and Susan Rhee and Diana Farmer and Kang, {Sang Mo} and Lane Bower and Debra Sudan and Mercer, {David F} and Antonson, {Dean L.} and Raynor, {Stephen C} and Brandy Sunderman and Kris Seipel and Martinez, {J. Andres} and Brent Polk and Martha Ballew and Carter, {Beth A.} and Mary Brandt and Saul Karpen and Sara Philips and Kristin Brown and {De La Torre}, Alejandro and Sara Fidanza and Frances Malone and Patrick Healey and Jorge Reyes and Cheryl Davis and Rudolph, {Jeffrey A.} and Samuel Kocoshis and Greg Tiao and Jacqueline Wessel and Riccardo Superina and Valeria Cohran and Kimberley Kazmerski and Lisa Keys and Margaret Richard and David Sigalet and Conrad Cole and Sharon Lawlor and Tamara Haller and Marcia Kurs-Lasky",
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T1 - Race affects outcome among infants with intestinal failure

AU - Squires, Robert H.

AU - Balint, Jane

AU - Horslen, Simon

AU - Wales, Paul W.

AU - Soden, Jason

AU - Duggan, Christopher

AU - Li, Ruosha

AU - Belle, Steven H.

AU - Burns, Cartland

AU - Mazariegos, George

AU - Nucci, Anita

AU - Yaworski, Jane Anne

AU - Sebbens, Danielle

AU - Cunningham, Rhonda

AU - Kamin, Daniel

AU - Jaksic, Tom

AU - Kim, Hueng Bae

AU - Collier, Sharon

AU - Connolly, Melanie

AU - Teitelbaum, Daniel H.

AU - Brown, Pamela

AU - Johnson, Michele

AU - Drongowski, Robert

AU - Valentine, Christina

AU - Teich, Steven

AU - Skaggs, Beth

AU - Venick, Robert

AU - Martin, Martin G.

AU - Beckwith, Patty

AU - Dunn, James

AU - Farmer, Douglas G.

AU - Reyen, Laurie

AU - Rhee, Susan

AU - Farmer, Diana

AU - Kang, Sang Mo

AU - Bower, Lane

AU - Sudan, Debra

AU - Mercer, David F

AU - Antonson, Dean L.

AU - Raynor, Stephen C

AU - Sunderman, Brandy

AU - Seipel, Kris

AU - Martinez, J. Andres

AU - Polk, Brent

AU - Ballew, Martha

AU - Carter, Beth A.

AU - Brandt, Mary

AU - Karpen, Saul

AU - Philips, Sara

AU - Brown, Kristin

AU - De La Torre, Alejandro

AU - Fidanza, Sara

AU - Malone, Frances

AU - Healey, Patrick

AU - Reyes, Jorge

AU - Davis, Cheryl

AU - Rudolph, Jeffrey A.

AU - Kocoshis, Samuel

AU - Tiao, Greg

AU - Wessel, Jacqueline

AU - Superina, Riccardo

AU - Cohran, Valeria

AU - Kazmerski, Kimberley

AU - Keys, Lisa

AU - Richard, Margaret

AU - Sigalet, David

AU - Cole, Conrad

AU - Lawlor, Sharon

AU - Haller, Tamara

AU - Kurs-Lasky, Marcia

PY - 2014/10/8

Y1 - 2014/10/8

N2 - Objective: Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF.Methods: This was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into ''white'' and ''nonwhite'' children.Results: Of 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P< 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P=0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center.Conclusions: Race is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF. Key Words: intestinal failure, intestinal transplant, outcome, race.

AB - Objective: Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF.Methods: This was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into ''white'' and ''nonwhite'' children.Results: Of 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P< 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P=0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center.Conclusions: Race is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF. Key Words: intestinal failure, intestinal transplant, outcome, race.

KW - Intestinal failure

KW - Intestinal transplant

KW - Outcome

KW - Race

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