Quiet connections: Reduced fronto-temporal connectivity in nondemented Parkinson's Disease during working memory encoding

Alex I. Wiesman, Elizabeth C Heinrichs-Graham, Timothy J. McDermott, Pamela M. Santamaria, Howard Eliot Gendelman, Tony W Wilson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a common neurodegenerative disorder characterized primarily by motor symptoms such as bradykinesia, muscle rigidity, and resting tremor. It is now broadly accepted that these motor symptoms frequently co-occur with cognitive impairments, with deficits in working memory and attention being among the most common cognitive sequelae associated with PD. While these cognitive impairments are now recognized, the underlying neural dynamics and precise regions involved remain largely unknown. To this end, we examined the oscillatory dynamics and interregional functional connectivity that serve working memory processing in a group of unmedicated adults with PD and a matched group without PD. Each participant completed a high-load, Sternberg-type working memory task during magnetoencephalography (MEG), and we focused on the encoding and maintenance phases. All data were transformed into the time–frequency domain and significant oscillatory activity was imaged using a beamforming approach. Phase-coherence (connectivity) was also computed among the brain subregions exhibiting the strongest responses. Our most important findings were that unmedicated patients with PD had significantly diminished working memory performance (i.e., accuracy), and reduced functional connectivity between left inferior frontal cortices and left supramarginal–superior temporal cortices compared to participants without PD during the encoding phase of working memory processing. We conclude that patients with PD have reduced neural interactions between left prefrontal executive circuits and temporary verbal storage centers in the left supramarginal/superior temporal cortices during the stimulus encoding phase, which may underlie their diminished working memory function. Hum Brain Mapp 37:3224–3235, 2016.

Original languageEnglish (US)
Pages (from-to)3224-3235
Number of pages12
JournalHuman Brain Mapping
Volume37
Issue number9
DOIs
StatePublished - Sep 1 2016

Fingerprint

Short-Term Memory
Parkinson Disease
Tremor
Temporal Lobe
Muscle Rigidity
Magnetoencephalography
Hypokinesia
Brain
Frontal Lobe
Neurodegenerative Diseases
Research Design
Maintenance

Keywords

  • cortical oscillations
  • local field potentials
  • magnetoencephalography
  • phase synchronization

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Quiet connections : Reduced fronto-temporal connectivity in nondemented Parkinson's Disease during working memory encoding. / Wiesman, Alex I.; Heinrichs-Graham, Elizabeth C; McDermott, Timothy J.; Santamaria, Pamela M.; Gendelman, Howard Eliot; Wilson, Tony W.

In: Human Brain Mapping, Vol. 37, No. 9, 01.09.2016, p. 3224-3235.

Research output: Contribution to journalArticle

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