Quetiapine therapy for posttraumatic stress disorder

S. Pirzada Sattar, Bernadette Ucci, Kathleen M Grant, Subhash C. Bhatia, Frederick Petty

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVE: To report a case of improvement in posttraumatic stress disorder (PTSD) after adjunctive therapy with quetiapine. CASE SUMMARY: A 49-year-old white man witnessed a traumatic event and experienced severe PTSD. He was started on paroxetine, with increases in dosage and no significant improvement. Quetiapine was added to his regimen, with increased doses resulting in improvement of PTSD symptoms, both clinically and as measured on the Hamilton-D rating scale for depression and the clinician-administered PTSD screen. DISCUSSION: This is the first case published in the English language literature describing improvement in PTSD symptoms after treatment with quetiapine. There are several treatment options for PTSD, but some severe cases may require treatment with antipsychotic medications. Because of the lower risks of serious adverse effects, the newer atypical antipsychotics are much safer than the older antipsychotics. Although use of risperidone and olanzapine in the successful treatment of PTSD has been reported in the literature, there are no reports of quetiapine use in this clinical condition. CONCLUSIONS: Quetiapine appeared to improve clinical signs and symptoms of PTSD in this patient. It may be a treatment option in other severe cases of PTSD.

Original languageEnglish (US)
Pages (from-to)1875-1878
Number of pages4
JournalAnnals of Pharmacotherapy
Volume36
Issue number12
DOIs
StatePublished - Dec 1 2002

Fingerprint

Post-Traumatic Stress Disorders
Antipsychotic Agents
Therapeutics
olanzapine
Quetiapine Fumarate
Paroxetine
Risperidone
Signs and Symptoms
Language
Depression

Keywords

  • PTSD
  • Posttraumatic stress disorder
  • Quetiapine

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Sattar, S. P., Ucci, B., Grant, K. M., Bhatia, S. C., & Petty, F. (2002). Quetiapine therapy for posttraumatic stress disorder. Annals of Pharmacotherapy, 36(12), 1875-1878. https://doi.org/10.1345/aph.1C040

Quetiapine therapy for posttraumatic stress disorder. / Sattar, S. Pirzada; Ucci, Bernadette; Grant, Kathleen M; Bhatia, Subhash C.; Petty, Frederick.

In: Annals of Pharmacotherapy, Vol. 36, No. 12, 01.12.2002, p. 1875-1878.

Research output: Contribution to journalArticle

Sattar, SP, Ucci, B, Grant, KM, Bhatia, SC & Petty, F 2002, 'Quetiapine therapy for posttraumatic stress disorder', Annals of Pharmacotherapy, vol. 36, no. 12, pp. 1875-1878. https://doi.org/10.1345/aph.1C040
Sattar, S. Pirzada ; Ucci, Bernadette ; Grant, Kathleen M ; Bhatia, Subhash C. ; Petty, Frederick. / Quetiapine therapy for posttraumatic stress disorder. In: Annals of Pharmacotherapy. 2002 ; Vol. 36, No. 12. pp. 1875-1878.
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