Quantitative evaluation of inflammation in biopsy specimens from idiopathically failing or irritable hearts: Experience in 80 pediatric and adult patients

Randal S. Cassling, James Linder, Thomas Delbert Sears, Bruce F. Waller, William C. Rogler, Janet E. Wilson, John Dale Kugler, David H. Kay, James C. Dillon, John D. Slack, Bruce M. McManus

Research output: Contribution to journalArticle

43 Scopus citations


The histologic criteria for the diagnosis of myocarditis on an endomyocardial biopsy specimen are troubled by varying institutional criteria and interobserver differences. A comprehensive approach to tissue evaluation including quantitative assessment of mononuclear cell populations enhances the accuracy and the specificity of the morphologic diagnosis. Future efforts to characterize the infiltrating cell lines in inflammatory conditions of the heart will aid in the ultimate refinement of therapeutic efficacy.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalAmerican Heart Journal
Issue number4
Publication statusPublished - Oct 1985


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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