Quantifying right atrial filling and emptying: A 4D-flow MRI study

Fraser M. Callaghan, Clare Arnott, Gemma A. Figtree, Shelby Kutty, David S. Celermajer, Stuart M. Grieve

Research output: Contribution to journalComment/debate

Abstract

Purpose: To quantitatively characterize the central role of vortex formation on the flow patterns and energy transfer within the right atrium (RA). Materials and Methods: 4D-flow magnetic resonance imaging (MRI) data with multiple encoding velocities was acquired in 12 healthy subjects at 3T. Particles entering the RA were classified according to the origin of entry. Vortex membership was numerically derived by assessing the location of pathline center of curvature relative to the vortex core, defined by Q-criteria. Flow dynamics and energetics were assessed using paired t-tests. Results: The majority of flow (74%) passes through the RA in a single beat, with a very small volume fraction retained longer than two beats (<1%). RA flow was dominated by a governing vortex, comprising 79% of total flow, and acting to preserve kinetic energy. Flow comprising the vortex enters the RA significantly earlier than nonvortex flow (P < 0.01). The majority of nonvortex flow enters the RA during systole, traversing the RA via a direct path with a significantly shorter residence time and distance traveled (both P < 0.01). Conclusion: Blood flow momentum is preserved during systole within a dominant vortex, which we are able to characterize numerically using a semiautomated approach. Our analytical approach has potential for application to understanding right heart function in health and disease. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:1–1.

Original languageEnglish (US)
JournalJournal of Magnetic Resonance Imaging
Volume45
Issue number4
DOIs
StatePublished - Apr 1 2017

Fingerprint

Heart Atria
Magnetic Resonance Imaging
Systole
Energy Transfer
Healthy Volunteers
Health

Keywords

  • fluid dynamics
  • four-dimensional flow
  • magnetic resonance imaging
  • right atrium

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Callaghan, F. M., Arnott, C., Figtree, G. A., Kutty, S., Celermajer, D. S., & Grieve, S. M. (2017). Quantifying right atrial filling and emptying: A 4D-flow MRI study. Journal of Magnetic Resonance Imaging, 45(4). https://doi.org/10.1002/jmri.25703

Quantifying right atrial filling and emptying : A 4D-flow MRI study. / Callaghan, Fraser M.; Arnott, Clare; Figtree, Gemma A.; Kutty, Shelby; Celermajer, David S.; Grieve, Stuart M.

In: Journal of Magnetic Resonance Imaging, Vol. 45, No. 4, 01.04.2017.

Research output: Contribution to journalComment/debate

Callaghan, Fraser M. ; Arnott, Clare ; Figtree, Gemma A. ; Kutty, Shelby ; Celermajer, David S. ; Grieve, Stuart M. / Quantifying right atrial filling and emptying : A 4D-flow MRI study. In: Journal of Magnetic Resonance Imaging. 2017 ; Vol. 45, No. 4.
@article{ec860570de354e01924609a95e34f0ea,
title = "Quantifying right atrial filling and emptying: A 4D-flow MRI study",
abstract = "Purpose: To quantitatively characterize the central role of vortex formation on the flow patterns and energy transfer within the right atrium (RA). Materials and Methods: 4D-flow magnetic resonance imaging (MRI) data with multiple encoding velocities was acquired in 12 healthy subjects at 3T. Particles entering the RA were classified according to the origin of entry. Vortex membership was numerically derived by assessing the location of pathline center of curvature relative to the vortex core, defined by Q-criteria. Flow dynamics and energetics were assessed using paired t-tests. Results: The majority of flow (74{\%}) passes through the RA in a single beat, with a very small volume fraction retained longer than two beats (<1{\%}). RA flow was dominated by a governing vortex, comprising 79{\%} of total flow, and acting to preserve kinetic energy. Flow comprising the vortex enters the RA significantly earlier than nonvortex flow (P < 0.01). The majority of nonvortex flow enters the RA during systole, traversing the RA via a direct path with a significantly shorter residence time and distance traveled (both P < 0.01). Conclusion: Blood flow momentum is preserved during systole within a dominant vortex, which we are able to characterize numerically using a semiautomated approach. Our analytical approach has potential for application to understanding right heart function in health and disease. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:1–1.",
keywords = "fluid dynamics, four-dimensional flow, magnetic resonance imaging, right atrium",
author = "Callaghan, {Fraser M.} and Clare Arnott and Figtree, {Gemma A.} and Shelby Kutty and Celermajer, {David S.} and Grieve, {Stuart M.}",
year = "2017",
month = "4",
day = "1",
doi = "10.1002/jmri.25703",
language = "English (US)",
volume = "45",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Quantifying right atrial filling and emptying

T2 - A 4D-flow MRI study

AU - Callaghan, Fraser M.

AU - Arnott, Clare

AU - Figtree, Gemma A.

AU - Kutty, Shelby

AU - Celermajer, David S.

AU - Grieve, Stuart M.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Purpose: To quantitatively characterize the central role of vortex formation on the flow patterns and energy transfer within the right atrium (RA). Materials and Methods: 4D-flow magnetic resonance imaging (MRI) data with multiple encoding velocities was acquired in 12 healthy subjects at 3T. Particles entering the RA were classified according to the origin of entry. Vortex membership was numerically derived by assessing the location of pathline center of curvature relative to the vortex core, defined by Q-criteria. Flow dynamics and energetics were assessed using paired t-tests. Results: The majority of flow (74%) passes through the RA in a single beat, with a very small volume fraction retained longer than two beats (<1%). RA flow was dominated by a governing vortex, comprising 79% of total flow, and acting to preserve kinetic energy. Flow comprising the vortex enters the RA significantly earlier than nonvortex flow (P < 0.01). The majority of nonvortex flow enters the RA during systole, traversing the RA via a direct path with a significantly shorter residence time and distance traveled (both P < 0.01). Conclusion: Blood flow momentum is preserved during systole within a dominant vortex, which we are able to characterize numerically using a semiautomated approach. Our analytical approach has potential for application to understanding right heart function in health and disease. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:1–1.

AB - Purpose: To quantitatively characterize the central role of vortex formation on the flow patterns and energy transfer within the right atrium (RA). Materials and Methods: 4D-flow magnetic resonance imaging (MRI) data with multiple encoding velocities was acquired in 12 healthy subjects at 3T. Particles entering the RA were classified according to the origin of entry. Vortex membership was numerically derived by assessing the location of pathline center of curvature relative to the vortex core, defined by Q-criteria. Flow dynamics and energetics were assessed using paired t-tests. Results: The majority of flow (74%) passes through the RA in a single beat, with a very small volume fraction retained longer than two beats (<1%). RA flow was dominated by a governing vortex, comprising 79% of total flow, and acting to preserve kinetic energy. Flow comprising the vortex enters the RA significantly earlier than nonvortex flow (P < 0.01). The majority of nonvortex flow enters the RA during systole, traversing the RA via a direct path with a significantly shorter residence time and distance traveled (both P < 0.01). Conclusion: Blood flow momentum is preserved during systole within a dominant vortex, which we are able to characterize numerically using a semiautomated approach. Our analytical approach has potential for application to understanding right heart function in health and disease. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:1–1.

KW - fluid dynamics

KW - four-dimensional flow

KW - magnetic resonance imaging

KW - right atrium

UR - http://www.scopus.com/inward/record.url?scp=85015243174&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85015243174&partnerID=8YFLogxK

U2 - 10.1002/jmri.25703

DO - 10.1002/jmri.25703

M3 - Comment/debate

AN - SCOPUS:85015243174

VL - 45

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 4

ER -