Quantifying mechanical properties in a murine fracture healing system using an inverse geometric nonlinear elasticity modeling framework

Michael I. Miga, Jared A. Weis, Froilan Granero-Molto, Anna Spagnoli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Understanding bone remodeling and mechanical property characteristics is important for assessing treatments to accelerate healing or in developing diagnostics to evaluate successful return to function. The murine system whereby mid-diaphaseal tibia fractures are imparted on the subject and fracture healing is assessed at different time points and under different therapeutic conditions is a particularly useful model to study. In this work, a novel inverse geometric nonlinear elasticity modeling framework is proposed that can reconstruct multiple mechanical properties from uniaxial testing data. This is investigated within the context of a murine cohort (n=3) that are 14 days post fracture. This work is the first to report mechanical properties of a callus using an inverse problem methodology whereby 2758.4 ± 682.5 kPa, 0.467 ± 0.009 were found to be the Young's modulus and Poisson's ratio, respectively. In addition better consistency of the reconstructed metrics over more traditional metrics is demonstrated.

Original languageEnglish (US)
Title of host publicationBiomedical Simulation - 5th International Symposium, ISBMS 2010, Proceedings
Pages29-37
Number of pages9
DOIs
StatePublished - Mar 25 2010
Event5th International Symposium on Biomedical Simulation, ISBMS 2010 - Phoenix, AZ, United States
Duration: Jan 23 2010Jan 24 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5958 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other5th International Symposium on Biomedical Simulation, ISBMS 2010
CountryUnited States
CityPhoenix, AZ
Period1/23/101/24/10

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Keywords

  • Elasticity
  • Finite element
  • Fracture healing
  • Inverse problems
  • Murine

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Miga, M. I., Weis, J. A., Granero-Molto, F., & Spagnoli, A. (2010). Quantifying mechanical properties in a murine fracture healing system using an inverse geometric nonlinear elasticity modeling framework. In Biomedical Simulation - 5th International Symposium, ISBMS 2010, Proceedings (pp. 29-37). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5958 LNCS). https://doi.org/10.1007/978-3-642-11615-5_4