Abstract
Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy.
| Original language | English (US) |
|---|---|
| Journal | Nutrients |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2019 |
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Keywords
- Carotenoid
- Lutein
- Placenta
- Pregnancy
- Zeaxanthin
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
Cite this
Quantification of lutein + zeaxanthin presence in human placenta and correlations with blood levels and maternal dietary intake. / Thoene, Melissa; Anderson Berry, Ann L; Van Ormer, Matthew; Furtado, Jeremy; Soliman, Ghada A.; Goldner, Whitney S; Hanson, Corrine K.
In: Nutrients, Vol. 11, No. 1, 01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quantification of lutein + zeaxanthin presence in human placenta and correlations with blood levels and maternal dietary intake
AU - Thoene, Melissa
AU - Anderson Berry, Ann L
AU - Van Ormer, Matthew
AU - Furtado, Jeremy
AU - Soliman, Ghada A.
AU - Goldner, Whitney S
AU - Hanson, Corrine K
PY - 2019/1
Y1 - 2019/1
N2 - Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy.
AB - Lutein + zeaxanthin (L + Z) are carotenoids recognized in eye health, but less is known about their status during pregnancy. While quantified in maternal and umbilical cord blood, they have never been analyzed in placenta. The purpose of this study is to quantify combined L + Z concentrations in human placenta and correlate with levels in maternal dietary intake, maternal serum, and umbilical cord blood. The proportions of combined L + Z were compared within diet, placenta, maternal serum, and umbilical cord blood among additional carotenoids (lycopene, β-cryptoxanthin, α-carotene, and β-carotene). This Institutional Review Boardapproved cross-sectional study enrolled 82 mother-infant pairs. Placenta, maternal serum, and umbilical cord blood samples were analyzed for carotenoids concentrations. Mothers completed a food frequency questionnaire and demographic/birth outcome data were collected. L + Z were present in placenta, median 0.105 micrograms/gram (mcg/g) and were significantly correlated with maternal serum (r = 0.57; p < 0.001), umbilical cord blood levels (r = 0.49; p = 0.001), but not dietary intake (p = 0.110). L + Z were the most prevalent in placenta (49.1%) umbilical cord blood (37.0%), but not maternal serum (18.6%) or dietary intake (19.4%). Rate of transfer was 16.0%, the highest of all carotenoids. Conclusively, L + Z were identified as the two most prevalent in placenta. Results highlight unique roles L + Z may play during pregnancy.
KW - Carotenoid
KW - Lutein
KW - Placenta
KW - Pregnancy
KW - Zeaxanthin
UR - http://www.scopus.com/inward/record.url?scp=85059895814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059895814&partnerID=8YFLogxK
U2 - 10.3390/nu11010134
DO - 10.3390/nu11010134
M3 - Article
C2 - 30634589
AN - SCOPUS:85059895814
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 1
ER -