Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking

Johannes T. Kowallick, Pablo Lamata, Shazia T. Hussain, Shelby Kutty, Michael Steinmetz, Jan M. Sohns, Martin Fasshauer, Wieland Staab, Christina Unterberg-Buchwald, Boris Bigalke, Joachim Lotz, Gerd Hasenfuß, Andreas Schuster

Research output: Contribution to journalArticle

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Abstract

Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).

Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.

Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.

Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.

Original languageEnglish (US)
Article numbere109164
JournalPloS one
Volume9
Issue number10
DOIs
StatePublished - Oct 6 2014

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Magnetic resonance
Torsional stress
Magnetic Resonance Spectroscopy
Dobutamine
reproducibility
Healthy Volunteers
volunteers
Interpolation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking. / Kowallick, Johannes T.; Lamata, Pablo; Hussain, Shazia T.; Kutty, Shelby; Steinmetz, Michael; Sohns, Jan M.; Fasshauer, Martin; Staab, Wieland; Unterberg-Buchwald, Christina; Bigalke, Boris; Lotz, Joachim; Hasenfuß, Gerd; Schuster, Andreas.

In: PloS one, Vol. 9, No. 10, e109164, 06.10.2014.

Research output: Contribution to journalArticle

Kowallick, JT, Lamata, P, Hussain, ST, Kutty, S, Steinmetz, M, Sohns, JM, Fasshauer, M, Staab, W, Unterberg-Buchwald, C, Bigalke, B, Lotz, J, Hasenfuß, G & Schuster, A 2014, 'Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking', PloS one, vol. 9, no. 10, e109164. https://doi.org/10.1371/journal.pone.0109164
Kowallick, Johannes T. ; Lamata, Pablo ; Hussain, Shazia T. ; Kutty, Shelby ; Steinmetz, Michael ; Sohns, Jan M. ; Fasshauer, Martin ; Staab, Wieland ; Unterberg-Buchwald, Christina ; Bigalke, Boris ; Lotz, Joachim ; Hasenfuß, Gerd ; Schuster, Andreas. / Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking. In: PloS one. 2014 ; Vol. 9, No. 10.
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abstract = "Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0{\%} LV distance) and basal (defined as 100{\%} LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75{\%}), Model-2 (0-100{\%}), Model-3 (25-100{\%}) and Model-4 (0-75{\%}). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75{\%}) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25{\%} and 75{\%} apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.",
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T1 - Quantification of left ventricular torsion and diastolic recoil using cardiovascular magnetic resonance myocardial feature tracking

AU - Kowallick, Johannes T.

AU - Lamata, Pablo

AU - Hussain, Shazia T.

AU - Kutty, Shelby

AU - Steinmetz, Michael

AU - Sohns, Jan M.

AU - Fasshauer, Martin

AU - Staab, Wieland

AU - Unterberg-Buchwald, Christina

AU - Bigalke, Boris

AU - Lotz, Joachim

AU - Hasenfuß, Gerd

AU - Schuster, Andreas

PY - 2014/10/6

Y1 - 2014/10/6

N2 - Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.

AB - Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 μg•kg-1•min-1) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values).Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach.Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 ± 1.5 cm-1, 3.6±2.0°cm-1, 5.1 ±2.2° cm-1, p< 0.01; Global Recoil Rate: -30.1 ±11.1°cm-1s-1,-46.9=15.0°cm-1s-1, -68.9±32.3°cm-1, p<0.01; for rest, 10 and 20 μg•kg-1•min-1 of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation.Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.

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