Quality of life in pancreatic cancer: Analysis by stage and treatment

Stefano Crippa, Ismael Domínguez, J. Ruben Rodríguez, Oswaldo Razo, Sarah P. Thayer, David P. Ryan, Andrew L. Warshaw, Carlos Fernández-Del Castillo

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

In pancreatic cancer patients, survival and palliation of symptoms should be balanced with social and functional impairment, and for this reason, health-related quality of life measurements could play an important role in the decision-making process. The aim of this work was to evaluate the quality of life and survival in 92 patients with different stages of pancreatic adenocarcinoma who underwent surgical and/or medical interventions. Patients were evaluated with the Functional Assessment of Cancer Therapy questionnaires at diagnosis and follow-up (3 and 6 months). At diagnosis, 28 patients (30.5%) had localized disease (group 1) and underwent surgical resection, 34 (37%) had locally advanced (group 2), and 30 (32.5%) metastatic disease (Group 3). Improvement in quality of life was found in group 1, while in group 3, it decreased at follow-up (p = 0.03). No changes in quality of life in group 2 were found. Chemotherapy/chemoradiation seems not to significantly modify quality of life in groups 2 and 3. Median survival time for the entire cohort was 9.8 months (range, 1-24). One-year survival was 74%, 30%, and 16% for groups 1, 2, and 3 respectively (p = 0.001). Pancreatic cancer prognosis is still dismal. In addition to long-term survival benefits, surgery impacts favorably quality of life.

Original languageEnglish (US)
Pages (from-to)783-794
Number of pages12
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number5
DOIs
StatePublished - May 1 2008

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Pancreatic Neoplasms
Quality of Life
Survival
Therapeutics
Decision Making
Adenocarcinoma
Drug Therapy
Neoplasms

Keywords

  • Meaningful important difference
  • Palliation
  • Pancreatic cancer
  • Quality of life
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Crippa, S., Domínguez, I., Rodríguez, J. R., Razo, O., Thayer, S. P., Ryan, D. P., ... Fernández-Del Castillo, C. (2008). Quality of life in pancreatic cancer: Analysis by stage and treatment. Journal of Gastrointestinal Surgery, 12(5), 783-794. https://doi.org/10.1007/s11605-007-0391-9

Quality of life in pancreatic cancer : Analysis by stage and treatment. / Crippa, Stefano; Domínguez, Ismael; Rodríguez, J. Ruben; Razo, Oswaldo; Thayer, Sarah P.; Ryan, David P.; Warshaw, Andrew L.; Fernández-Del Castillo, Carlos.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 5, 01.05.2008, p. 783-794.

Research output: Contribution to journalArticle

Crippa, S, Domínguez, I, Rodríguez, JR, Razo, O, Thayer, SP, Ryan, DP, Warshaw, AL & Fernández-Del Castillo, C 2008, 'Quality of life in pancreatic cancer: Analysis by stage and treatment', Journal of Gastrointestinal Surgery, vol. 12, no. 5, pp. 783-794. https://doi.org/10.1007/s11605-007-0391-9
Crippa, Stefano ; Domínguez, Ismael ; Rodríguez, J. Ruben ; Razo, Oswaldo ; Thayer, Sarah P. ; Ryan, David P. ; Warshaw, Andrew L. ; Fernández-Del Castillo, Carlos. / Quality of life in pancreatic cancer : Analysis by stage and treatment. In: Journal of Gastrointestinal Surgery. 2008 ; Vol. 12, No. 5. pp. 783-794.
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