Controle de qualite des monodoses de 7 principes actifs

Translated title of the contribution: Quality control of 7 drugs unit doses

D. Feldman, O. Ghribi, J. Ouary, G. Dumortier, K. Degrassat, R. Leverge

Research output: Contribution to journalArticle

2 Scopus citations


The stability of 7 drugs (alimemazine, amitriptyline, chlorpromazine, cyamemazine, heptaminol, periciazine and sodium valproate) in unit dose solution packaged in ambercoloured glass vial was studied using different concentrations, both at 4 °C and 30 °C, along 28 days. The solution was obtained from the dilution of commercially available oral solution. The determinations were carried out by high performance liquid chromatography using an UV spectrophotometric detection. The loss was always inferior to 5% for chlorpromazine and cyamemazine solutions. A loss superior to 10% was detected in the case of heptaminol, periciazine and sodium valproate.

Original languageFrench
Pages (from-to)268-271
Number of pages4
JournalJournal de Pharmacie Clinique
Issue number4
StatePublished - Dec 1 1998



  • Aqueous solution
  • Dilution
  • Glass
  • Psychotric drugs
  • Stability
  • Unit dose

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Feldman, D., Ghribi, O., Ouary, J., Dumortier, G., Degrassat, K., & Leverge, R. (1998). Controle de qualite des monodoses de 7 principes actifs. Journal de Pharmacie Clinique, 17(4), 268-271.