Qualitative and quantitative analyses of resin-bound organic compounds

Mark Irving, Jason Cournoyer, Rongshi Li, Chris Santos, Bing Yan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.

Original languageEnglish (US)
Pages (from-to)353-362
Number of pages10
JournalCombinatorial Chemistry and High Throughput Screening
Volume4
Issue number4
DOIs
StatePublished - Jan 1 2001

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Organic compounds
Resins
Ion-Selective Electrodes
Solid-Phase Synthesis Techniques
Spectrophotometry
Fluorides
Gels
Nuclear magnetic resonance
Monitoring

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

Cite this

Qualitative and quantitative analyses of resin-bound organic compounds. / Irving, Mark; Cournoyer, Jason; Li, Rongshi; Santos, Chris; Yan, Bing.

In: Combinatorial Chemistry and High Throughput Screening, Vol. 4, No. 4, 01.01.2001, p. 353-362.

Research output: Contribution to journalArticle

Irving, Mark ; Cournoyer, Jason ; Li, Rongshi ; Santos, Chris ; Yan, Bing. / Qualitative and quantitative analyses of resin-bound organic compounds. In: Combinatorial Chemistry and High Throughput Screening. 2001 ; Vol. 4, No. 4. pp. 353-362.
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