PYY in the expanding pancreatic epithelium

Guoxun Liu, Sandrine Arnaud-Dabernat, Marcie R. Kritzik, Ayse G. Kayali, You Qing Zhang, Nora Sarvetnick

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Gut peptide YY (PYY) plays an important role in regulating metabolism and is expressed during the ontogeny of the pancreas. However, its biological role during endocrine cell formation is not fully understood, and its role, if any, during pancreatic regeneration in the adult has not yet been explored. The knowledge of factors involved in beta cell renewal in adult animals is clearly relevant for the design of treatment strategies for type 1 diabetes. We therefore sought to determine if observations during fetal pancreas formation also apply to pancreatic growth in adult animals. Indeed, we have found marked expansion of the PYY-expressing population during pancreatic regeneration. In addition, we demonstrate the presence of cells co-expressing PYY and the critical pancreatic transcription factor pancreatic duodenal homeobox1 (PDX-1). Interestingly, these cells also co-expressed specific islet hormones during pancreatic development and re-growth, suggesting a developmental relationship. Furthermore, we have found that PYY can act in concert with IGF-1 to stimulate cellular responsiveness in pancreatic epithelial cells in vitro. Our data suggest that PYY may be a mediator of islet cell development, as well as a cofactor for growth factor responses, not only during fetal pancreas formation but also during regeneration in adult animals.

Original languageEnglish (US)
Pages (from-to)103-112
Number of pages10
JournalEndocrine
Volume30
Issue number1
DOIs
StatePublished - Aug 1 2006

Fingerprint

Peptide YY
Epithelium
Regeneration
Pancreas
Pancreatic Hormones
Endocrine Cells
Type 1 Diabetes Mellitus
Insulin-Like Growth Factor I
Islets of Langerhans
Growth and Development
Intercellular Signaling Peptides and Proteins
Transcription Factors
Epithelial Cells
Growth
Population

Keywords

  • Neogenesis
  • PYY
  • Pancreas
  • Regeneration

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Liu, G., Arnaud-Dabernat, S., Kritzik, M. R., Kayali, A. G., Zhang, Y. Q., & Sarvetnick, N. (2006). PYY in the expanding pancreatic epithelium. Endocrine, 30(1), 103-112. https://doi.org/10.1385/ENDO:30:1:103

PYY in the expanding pancreatic epithelium. / Liu, Guoxun; Arnaud-Dabernat, Sandrine; Kritzik, Marcie R.; Kayali, Ayse G.; Zhang, You Qing; Sarvetnick, Nora.

In: Endocrine, Vol. 30, No. 1, 01.08.2006, p. 103-112.

Research output: Contribution to journalArticle

Liu, G, Arnaud-Dabernat, S, Kritzik, MR, Kayali, AG, Zhang, YQ & Sarvetnick, N 2006, 'PYY in the expanding pancreatic epithelium', Endocrine, vol. 30, no. 1, pp. 103-112. https://doi.org/10.1385/ENDO:30:1:103
Liu G, Arnaud-Dabernat S, Kritzik MR, Kayali AG, Zhang YQ, Sarvetnick N. PYY in the expanding pancreatic epithelium. Endocrine. 2006 Aug 1;30(1):103-112. https://doi.org/10.1385/ENDO:30:1:103
Liu, Guoxun ; Arnaud-Dabernat, Sandrine ; Kritzik, Marcie R. ; Kayali, Ayse G. ; Zhang, You Qing ; Sarvetnick, Nora. / PYY in the expanding pancreatic epithelium. In: Endocrine. 2006 ; Vol. 30, No. 1. pp. 103-112.
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