Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response

Donghoon Kang, Daniel R. Kirienkoa, Phillip Webster, Alfred L. Fisher, Natalia V. Kirienko

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections. This observation is generally attributed to its roles in acquiring iron and/or regulating other virulence factors. Here we report that pyoverdine translocates into the host, where it binds and extracts iron. Pyoverdine-mediated iron extraction damages host mitochondria, disrupting their function and triggering mitochondrial turnover via autophagy. The host detects this damage via a conserved mitochondrial surveillance pathway mediated by the ESRE network. Our findings illuminate the pathogenic mechanisms of pyoverdine and highlight the importance of this bacterial product in host-pathogen interactions.

Original languageEnglish (US)
Pages (from-to)804-817
Number of pages14
JournalVirulence
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Siderophores
Pseudomonas aeruginosa
Iron
Mitochondrial Turnover
Host-Pathogen Interactions
Autophagy
Virulence Factors
Virulence
Mitochondria
Bacteria
pyoverdin
Infection

Keywords

  • Caenorhabditis elegans
  • Host response
  • Mitochondrial damage
  • Pathogenesis
  • Pseudomonas aeruginosa
  • Pyoverdine
  • Siderophore

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. / Kang, Donghoon; Kirienkoa, Daniel R.; Webster, Phillip; Fisher, Alfred L.; Kirienko, Natalia V.

In: Virulence, Vol. 9, No. 1, 01.01.2018, p. 804-817.

Research output: Contribution to journalArticle

Kang, Donghoon ; Kirienkoa, Daniel R. ; Webster, Phillip ; Fisher, Alfred L. ; Kirienko, Natalia V. / Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response. In: Virulence. 2018 ; Vol. 9, No. 1. pp. 804-817.
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