Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells

J. M. Kamath, B. E. Britigan, C. D. Cox, D. M. Shasby

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might alter vascular homeostasis in the absence of cytolysis.

Original languageEnglish (US)
Pages (from-to)4921-4923
Number of pages3
JournalInfection and immunity
Volume63
Issue number12
StatePublished - Jan 1 1995

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Pyocyanine
Epoprostenol
Pseudomonas aeruginosa
Pulmonary Artery
Endothelial Cells
Vasculitis
Endothelium
Blood Vessels
Pneumonia
Homeostasis
Necrosis
Bacteria

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells. / Kamath, J. M.; Britigan, B. E.; Cox, C. D.; Shasby, D. M.

In: Infection and immunity, Vol. 63, No. 12, 01.01.1995, p. 4921-4923.

Research output: Contribution to journalArticle

Kamath, J. M. ; Britigan, B. E. ; Cox, C. D. ; Shasby, D. M. / Pyocyanin from Pseudomonas aeruginosa inhibits prostacyclin release from endothelial cells. In: Infection and immunity. 1995 ; Vol. 63, No. 12. pp. 4921-4923.
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