Purkinje cell dendrites grow in alignment with Bergmann glia

Tamar Lordkipanidze, Anna Dunaevsky

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

The pattern of growth of Purkinje cell dendrites has been analyzed and related to their interactions with Bergmann glial radial processes. In cerebellar slice cultures from mice expressing green fluorescent protein (GFP) under the glial fibrillary acidic protein (GFAP) promoter, Purkinje cells were transfected and imaged with two-photon microscopy over 2 days. We report that while the Purkinje cell dendritic tree grows, individual dendrites increase or decrease in length. Importantly, we demonstrate that vertical growth of Purkinje cell dendrites occurs primarily in alignment with radial glial processes. These findings suggest that radial glial processes provide a structural substrate for the directional growth of Purkinje cell dendrites, thus influencing the shape of the dendritic tree.

Original languageEnglish (US)
Pages (from-to)229-234
Number of pages6
JournalGlia
Volume51
Issue number3
DOIs
StatePublished - Aug 15 2005

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Keywords

  • Astrocytes
  • Bergmann glia
  • Cerebellum
  • Dendrites
  • Two-photon microscopy

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

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