Pure red cell aplasia following ABO mismatched marrow transplantation for chronic lymphocytic leukemia

Response to antithymocyte globulin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pure red cell aplasia was observed in a 28 year old woman following a major ABO mismatched allogeneic bone marrow transplant for chronic lymphocytic leukemia. No evidence of red Blood cell production was observed for more than one year following transplant despite the absence of high isohemagglutinin titers. Treatment with antithymocyte globulin resulted in prompt restoration of reticulocytosis. Therapy with antithymocyte globulin should be considered in these instances when red cell aplasia follows mismatched allogeneic marrow transplantation.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalLeukemia and Lymphoma
Volume9
Issue number1-2
DOIs
StatePublished - Jan 1 1993

Fingerprint

Pure Red-Cell Aplasia
Antilymphocyte Serum
B-Cell Chronic Lymphocytic Leukemia
Transplantation
Bone Marrow
Reticulocytosis
Transplants
Homologous Transplantation
Hemagglutinins
Erythrocytes
Therapeutics

Keywords

  • ABO mismatched marrow transplantation
  • Antithymocyte globulin
  • Bone marrow transplantation
  • Chronic lymphocytic leukemia
  • Red Blood cell aplasia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Pure red cell aplasia following ABO mismatched marrow transplantation for chronic lymphocytic leukemia: Response to antithymocyte globulin",
abstract = "Pure red cell aplasia was observed in a 28 year old woman following a major ABO mismatched allogeneic bone marrow transplant for chronic lymphocytic leukemia. No evidence of red Blood cell production was observed for more than one year following transplant despite the absence of high isohemagglutinin titers. Treatment with antithymocyte globulin resulted in prompt restoration of reticulocytosis. Therapy with antithymocyte globulin should be considered in these instances when red cell aplasia follows mismatched allogeneic marrow transplantation.",
keywords = "ABO mismatched marrow transplantation, Antithymocyte globulin, Bone marrow transplantation, Chronic lymphocytic leukemia, Red Blood cell aplasia",
author = "Bierman, {Philip Jay} and Warkentin, {Phyllis Irene} and Hutchins, {Mark R.} and Klassen, {Lynell Warren}",
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T1 - Pure red cell aplasia following ABO mismatched marrow transplantation for chronic lymphocytic leukemia

T2 - Response to antithymocyte globulin

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AU - Warkentin, Phyllis Irene

AU - Hutchins, Mark R.

AU - Klassen, Lynell Warren

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N2 - Pure red cell aplasia was observed in a 28 year old woman following a major ABO mismatched allogeneic bone marrow transplant for chronic lymphocytic leukemia. No evidence of red Blood cell production was observed for more than one year following transplant despite the absence of high isohemagglutinin titers. Treatment with antithymocyte globulin resulted in prompt restoration of reticulocytosis. Therapy with antithymocyte globulin should be considered in these instances when red cell aplasia follows mismatched allogeneic marrow transplantation.

AB - Pure red cell aplasia was observed in a 28 year old woman following a major ABO mismatched allogeneic bone marrow transplant for chronic lymphocytic leukemia. No evidence of red Blood cell production was observed for more than one year following transplant despite the absence of high isohemagglutinin titers. Treatment with antithymocyte globulin resulted in prompt restoration of reticulocytosis. Therapy with antithymocyte globulin should be considered in these instances when red cell aplasia follows mismatched allogeneic marrow transplantation.

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KW - Bone marrow transplantation

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KW - Red Blood cell aplasia

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