Pulmonary lymphomatoid granulomatosis in a dog: Evidence of immunophenotypic diversity and relationship to human pulmonary lymphomatoid granulomatosis and pulmonary Hodgkin's disease

H. M. Park, D. N. Hwang, B. T. Kang, D. I. Jung, G. S. Song, S. J. Lee, J. Y. Yhee, C. H. Yu, Alan R Doster, Jung Hyang Sur

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15 Scopus citations


We describe a 10-month-old, intact female American Cocker Spaniel with pulmonary lymphomatoid granulomatosis (PLG). On clinical examination, this dog presented with nonproductive dry cough, serous nasal discharge, dyspnea, and lack of appetite. Radiography showed a consolidated lesion in the left cranial lung lobe. Histopathologic examination showed a mixed population of atypical lymphoid cells that had infiltrated into the pulmonary blood vessels angiocentrically. The lymphocytes were CD3 positive, consistent with a pan-T-cell phenotype. The lymphoid cells in the lesion were also positive for CD20cy and CD79a, indicative of the presence of B cells. We also observed large Reed-Sternberg-like cells that were positive for CD15 and CD30, similar to observations in human pulmonary Hodgkin's disease (PHD). In conclusion, canine PLG in this Cocker Spaniel was associated with B and T cells, which is first identified in a case of canine PLG. It was histopathologically similar to human lymphomatoid granulomatosis and immunophenotypically similar to human PHD.

Original languageEnglish (US)
Pages (from-to)921-923
Number of pages3
JournalVeterinary pathology
Issue number6
Publication statusPublished - Nov 1 2007



  • Dogs
  • Immunohistochemistry
  • Pulmonary Hodgkin's disease
  • Pulmonary lymphomatoid granulomatosis

ASJC Scopus subject areas

  • veterinary(all)

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