Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska

Stephen J. Reynolds, Maggie L. Clark, Niels Koehncke, Susanna G Von Essen, Linda Prinz, Thomas J. Keefe, John Mehaffy, Mary Bradford, Brian Cranmer, Margaret E. Davidson, Ivana V. Yang, James B. Burch

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

OBJECTIVE: Organic dust inhalation has been associated with adverse respiratory responses among agricultural workers. We evaluated factors that may confer increased susceptibility to these health effects. METHODS: We quantified personal work shift exposures to inhalable dust, endotoxin, and its 3-hydroxy fatty acid constituents, and evaluated changes in pulmonary function among 137 grain elevator, cattle feedlot, dairy, and corn farm workers. RESULTS: Increased dust exposure was associated with work shift reductions in lung function. Although interpretation is limited because of small samples, a suggestion of stronger exposure-response relationships was observed among smokers, as well as workers reporting pesticide/herbicide application, asthma, or allergies, and those with genetic polymorphisms (TLR4) (Pinteraction ≤ 0.05). CONCLUSIONS: A better understanding of factors leading to increased susceptibility of adverse respiratory outcomes is needed to optimize exposure reduction strategies and develop more comprehensive wellness programs.

Original languageEnglish (US)
Pages (from-to)632-641
Number of pages10
JournalJournal of Occupational and Environmental Medicine
Volume54
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Dust
Lung
Elevators and Escalators
Hydroxy Acids
Herbicides
Genetic Polymorphisms
Health Promotion
Pesticides
Endotoxins
Inhalation
Zea mays
Hypersensitivity
Fatty Acids
Asthma
Health
Farmers

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska. / Reynolds, Stephen J.; Clark, Maggie L.; Koehncke, Niels; Von Essen, Susanna G; Prinz, Linda; Keefe, Thomas J.; Mehaffy, John; Bradford, Mary; Cranmer, Brian; Davidson, Margaret E.; Yang, Ivana V.; Burch, James B.

In: Journal of Occupational and Environmental Medicine, Vol. 54, No. 5, 01.05.2012, p. 632-641.

Research output: Contribution to journalReview article

Reynolds, SJ, Clark, ML, Koehncke, N, Von Essen, SG, Prinz, L, Keefe, TJ, Mehaffy, J, Bradford, M, Cranmer, B, Davidson, ME, Yang, IV & Burch, JB 2012, 'Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska', Journal of Occupational and Environmental Medicine, vol. 54, no. 5, pp. 632-641. https://doi.org/10.1097/JOM.0b013e31824d2e1c
Reynolds, Stephen J. ; Clark, Maggie L. ; Koehncke, Niels ; Von Essen, Susanna G ; Prinz, Linda ; Keefe, Thomas J. ; Mehaffy, John ; Bradford, Mary ; Cranmer, Brian ; Davidson, Margaret E. ; Yang, Ivana V. ; Burch, James B. / Pulmonary function reductions among potentially susceptible subgroups of agricultural workers in Colorado and Nebraska. In: Journal of Occupational and Environmental Medicine. 2012 ; Vol. 54, No. 5. pp. 632-641.
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