Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs

H. D. Schultz, A. M. Roberts, C. Bratcher, H. M. Coleridge, J. C. Coleridge, B. Davis

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Stimulation of bronchial C-fibers evokes a reflex increase in secretion by tracheal submucosal glands, but the influence of pulmonary C-fibers on tracheal gland secretion is uncertain. In anesthetized dogs with open chests, we sprayed powdered tantalum on the exposed mucosa of a segment of the upper trachea to measure the rate of secretion by submucosal glands. Secretions from the gland ducts caused elevations (hillocks) in the tantalum layer. We counted hillocks at 10-s intervals for 60 s before and 60 s after we injected capsaicin (10-20 μg/kg) into the right atrium to stimulate pulmonary C-fiber endings. Right atrial injection of capsaicin increased the rate of hillock formation 4-fold, but left atrial injection had no significant effect. The response was abolished by cutting the vagus nerves or cooling them to 0° C. We conclude that the reflex increase in tracheal submucosal gland secretion evoked by right atrial injection of capsaicin was initiated as capsaicin passed through the pulmonary vascular bed, and hence that pulmonary C-fibers, like bronchial C-fibers, reflexly increase airway secretion.

Original languageEnglish (US)
Pages (from-to)907-910
Number of pages4
JournalJournal of Applied Physiology
Volume58
Issue number3
StatePublished - Aug 28 1985
Externally publishedYes

Fingerprint

Unmyelinated Nerve Fibers
Capsaicin
Dogs
Lung
Tantalum
Injections
Reflex
Vagus Nerve
Trachea
Heart Atria
Blood Vessels
Mucous Membrane
Thorax

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Schultz, H. D., Roberts, A. M., Bratcher, C., Coleridge, H. M., Coleridge, J. C., & Davis, B. (1985). Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. Journal of Applied Physiology, 58(3), 907-910.

Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. / Schultz, H. D.; Roberts, A. M.; Bratcher, C.; Coleridge, H. M.; Coleridge, J. C.; Davis, B.

In: Journal of Applied Physiology, Vol. 58, No. 3, 28.08.1985, p. 907-910.

Research output: Contribution to journalArticle

Schultz, HD, Roberts, AM, Bratcher, C, Coleridge, HM, Coleridge, JC & Davis, B 1985, 'Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs', Journal of Applied Physiology, vol. 58, no. 3, pp. 907-910.
Schultz HD, Roberts AM, Bratcher C, Coleridge HM, Coleridge JC, Davis B. Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. Journal of Applied Physiology. 1985 Aug 28;58(3):907-910.
Schultz, H. D. ; Roberts, A. M. ; Bratcher, C. ; Coleridge, H. M. ; Coleridge, J. C. ; Davis, B. / Pulmonary C-fibers reflexly increase secretion by tracheal submucosal glands in dogs. In: Journal of Applied Physiology. 1985 ; Vol. 58, No. 3. pp. 907-910.
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