PTSD, alcohol dependence, and conduct problems: Distinct pathways via lability and disinhibition

Jeffrey S. Simons, Raluca M. Simons, Carol O'Brien, Scott F. Stoltenberg, Jessica A. Keith, Jaime A. Hudson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study tested the role of affect lability and disinhibition in mediating associations between PTSD symptoms and two forms of alcohol-related problems, dependence syndrome symptoms (e.g., impaired control over consumption) and conduct problems (e.g., assault, risk behaviors). Genotype at the serotonin transporter linked polymorphic region (5-HTTLPR) was hypothesized to moderate associations between traumatic stress and PTSD symptoms. In addition, the study tested whether childhood traumatic stress moderated associations between combat trauma and PTSD symptoms. Participants were 270 OIF/OEF/OND veterans. The hypothesized model was largely supported. Participants with the low expression alleles of 5-HTTLPR (S or LG) exhibited stronger associations between childhood (but not combat) traumatic stress and PTSD symptoms. Affect lability mediated the associations between PTSD symptoms and alcohol dependence symptoms. Behavioral disinhibition mediated associations between PTSD symptoms and conduct related problems. Conditional indirect effects indicated stronger associations between childhood traumatic stress and lability, behavioral disinhibition, alcohol consumption, AUD symptoms, and associated conduct problems via PTSD symptoms among those with the low expression 5-HTTLPR alleles. However, interactions between combat trauma and either childhood trauma or genotype were not significant. The results support the hypothesis that affect lability and behavioral disinhibition are potential intermediate traits with distinct associations with AUD and associated externalizing problems.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalAddictive Behaviors
Volume64
DOIs
StatePublished - Jan 1 2017

Fingerprint

Post-Traumatic Stress Disorders
Alcoholism
Alcohols
Serotonin Plasma Membrane Transport Proteins
2003-2011 Iraq War
Wounds and Injuries
Alleles
Genotype
Veterans
Risk-Taking
Alcohol Drinking

Keywords

  • Affect dysregulation
  • Alcohol use disorder
  • PTSD
  • SLC6A4
  • rs25531

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Toxicology
  • Psychiatry and Mental health

Cite this

PTSD, alcohol dependence, and conduct problems : Distinct pathways via lability and disinhibition. / Simons, Jeffrey S.; Simons, Raluca M.; O'Brien, Carol; Stoltenberg, Scott F.; Keith, Jessica A.; Hudson, Jaime A.

In: Addictive Behaviors, Vol. 64, 01.01.2017, p. 185-193.

Research output: Contribution to journalArticle

Simons, Jeffrey S. ; Simons, Raluca M. ; O'Brien, Carol ; Stoltenberg, Scott F. ; Keith, Jessica A. ; Hudson, Jaime A. / PTSD, alcohol dependence, and conduct problems : Distinct pathways via lability and disinhibition. In: Addictive Behaviors. 2017 ; Vol. 64. pp. 185-193.
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