Proton spectroscopy of brain glutamine in acute liver failure

James R. McConnell, Dean L. Antonson, Chin Siong Ong, Wei Kom Chu, Ira J. Fox, Thomas G. Heffron, Alan Norman Langnas, Byers W. Shaw

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalHepatology
Volume22
Issue number1
DOIs
StatePublished - Jul 1995

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Acute Liver Failure
Glutamine
Protons
Spectrum Analysis
Brain
Brain Diseases
Proton Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Hepatology

Cite this

McConnell, J. R., Antonson, D. L., Ong, C. S., Chu, W. K., Fox, I. J., Heffron, T. G., ... Shaw, B. W. (1995). Proton spectroscopy of brain glutamine in acute liver failure. Hepatology, 22(1), 69-74. https://doi.org/10.1016/0270-9139(95)90354-2

Proton spectroscopy of brain glutamine in acute liver failure. / McConnell, James R.; Antonson, Dean L.; Ong, Chin Siong; Chu, Wei Kom; Fox, Ira J.; Heffron, Thomas G.; Langnas, Alan Norman; Shaw, Byers W.

In: Hepatology, Vol. 22, No. 1, 07.1995, p. 69-74.

Research output: Contribution to journalArticle

McConnell, JR, Antonson, DL, Ong, CS, Chu, WK, Fox, IJ, Heffron, TG, Langnas, AN & Shaw, BW 1995, 'Proton spectroscopy of brain glutamine in acute liver failure', Hepatology, vol. 22, no. 1, pp. 69-74. https://doi.org/10.1016/0270-9139(95)90354-2
McConnell JR, Antonson DL, Ong CS, Chu WK, Fox IJ, Heffron TG et al. Proton spectroscopy of brain glutamine in acute liver failure. Hepatology. 1995 Jul;22(1):69-74. https://doi.org/10.1016/0270-9139(95)90354-2
McConnell, James R. ; Antonson, Dean L. ; Ong, Chin Siong ; Chu, Wei Kom ; Fox, Ira J. ; Heffron, Thomas G. ; Langnas, Alan Norman ; Shaw, Byers W. / Proton spectroscopy of brain glutamine in acute liver failure. In: Hepatology. 1995 ; Vol. 22, No. 1. pp. 69-74.
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