We performed single-voxel proton MR spectroscopy (1H-MRS) in two children with Sjogren-Larsson's syndrome (SLS). Both patients showed two abnormal spectral peaks at 1.3 ppm and 0.9 ppm that were obtained with short echo times. These two abnormal spectral peaks were seen in high-intensity areas on T2-weighted images and also in basal ganglia of normal intensities. 1H-MRS may be useful for establishing the diagnosis and investigating the natural history of SLS, and for evaluating the efficacy of therapeutic approaches to SLS.
|Original language||English (US)|
|Number of pages||3|
|Journal||American Journal of Neuroradiology|
|Publication status||Published - Nov 4 1999|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology