Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system Whipple disease

Jared W. Nelson, Matthew L. White, Yan Zhang, Toshio Moritani

Research output: Contribution to journalArticle

10 Scopus citations


A 72-year-old man presented with a 6-month history of dysphagia, fatigue, 60-lb weight loss, and central nervous system (CNS) deficits. Diffusion-weighted magnetic resonance imaging (MRI) of the brain showed mildly elevated nonrestricted apparent diffusion coefficients in the middle cerebellar peduncles, and magnetic resonance spectroscopy (MRS) showed decreased N-acetylaspartate and creatine with increased choline. Diffusion-weighted MRI and MRS offer non-invasive methods to help evaluate in vivo physiologic changes of CNS involvement in Whipple disease.

Original languageEnglish (US)
Pages (from-to)320-322
Number of pages3
JournalJournal of Computer Assisted Tomography
Issue number3
StatePublished - May 1 2005



  • Central nervous system infections
  • Diffusion-weighted imaging
  • Magnetic resonance spectroscopy
  • Whipple disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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