6 Citations (Scopus)

Abstract

Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.

Original languageEnglish (US)
Pages (from-to)8371-8374
Number of pages4
JournalChemical Communications
Volume54
Issue number60
DOIs
StatePublished - Jan 1 2018

Fingerprint

Macrophages
carbovir triphosphate
abacavir

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

ProTide generated long-acting abacavir nanoformulations. / Lin, Zhiyi; Gautam, Nagsen; Alnouti, Yazen; McMillan, JoEllyn M; Bade, Aditya N.; Gendelman, Howard Eliot; Edagwa, Benson J.

In: Chemical Communications, Vol. 54, No. 60, 01.01.2018, p. 8371-8374.

Research output: Contribution to journalArticle

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abstract = "Abacavir pronucleotide nanoformulations (NM3ABC) were prepared as a novel long acting slow effective release antiretroviral therapy. Single NM3ABC treatment of human monocyte-derived macrophages produced sustained intracellular carbovir-triphosphate and antiretroviral activities for up to 30 days.",
author = "Zhiyi Lin and Nagsen Gautam and Yazen Alnouti and McMillan, {JoEllyn M} and Bade, {Aditya N.} and Gendelman, {Howard Eliot} and Edagwa, {Benson J}",
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AU - Lin, Zhiyi

AU - Gautam, Nagsen

AU - Alnouti, Yazen

AU - McMillan, JoEllyn M

AU - Bade, Aditya N.

AU - Gendelman, Howard Eliot

AU - Edagwa, Benson J

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