Protein microspheres from corn as a sustained drug delivery system

Jin Ye Wang, Hua Jie Wang, Xin Ming Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Zein, as a sustained release material, was developed that permits continuous release of biologically active molecules from the microspheres, films and tablets. Ivermectin and heparin were chosen as the fat-soluble and the water-soluble model drugs, respectively. The heparin-loaded film or the ivermectin-loaded tablet were prepared based on drug-loaded zein microspheres that were obtained by the phase separation method and characterized by a scanning electron microscope and laser light scattering particle size analyzer. The biocompatibility of zein was evaluated, including human umbilical veins endothelial cells compatibility and hemocompatibility. Then the release in vitro and activity of drugs from the microspheres, films and tablets were determined. The results showed that zein and its degraded product had better biocompatibility; the sizes of microspheres could be controlled in 10nm-10μm and affected by the preparation conditions, such as concentrations of zein and drugs. Drugs in microspheres, films and tablets could be released slowly, in the mechanism of the diffusion of drugs through the matrix. Moreover, the drugs still kept the high activity.

Original languageEnglish (US)
Title of host publicationNew Delivery Systems for Controlled Drug Release from Naturally Occurring Materials
PublisherAmerican Chemical Society
Pages209-241
Number of pages33
ISBN (Print)9780841274242
DOIs
Publication statusPublished - Nov 7 2008

Publication series

NameACS Symposium Series
Volume992
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

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ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Wang, J. Y., Wang, H. J., & Liu, X. M. (2008). Protein microspheres from corn as a sustained drug delivery system. In New Delivery Systems for Controlled Drug Release from Naturally Occurring Materials (pp. 209-241). (ACS Symposium Series; Vol. 992). American Chemical Society. https://doi.org/10.1021/bk-2008-0992.ch012