Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors

J. E. Talmadge, H. Tribble, R. Pennington, O. Bowersox, M. A. Schneider, P. Castelli, P. L. Black, F. Abe

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Pretreatment of mice with recombinant murine (rM) colony-stimulating factor-granulocyte-macrophage (CSF-gm) or recombinant human (rH) CSF-g provides partial protection from the lethal effects of ionizing radiation or the alkylating agent cyclophosphamide (CTX). In addition, these agents can significantly prolong survival if administered following lethal doses of irradiation or CTX. To induce protective activity, cytokines were injected 20 hours before lethal irradiation or CTX administration. To accelerate recovery from lethal irradiation, the cytokines must be administered shortly following irradiation, and the induction of maximal levels of activity is dependent on chronic administration. In contrast, because of their longer half-lives, accelerated recovery from alkylating agents requires a delay of at least 24 to 48 hours to allow complete clearance of CTX before administration of a CSF. Studies quantitating peripheral blood leukocytes and bone marrow cellularity as well as colony-forming units per culture (CFU-C) frequency and CFU-C per femur revealed a significant correlation between these parameters and the ability to survive lethal irradiation.

Original languageEnglish (US)
Pages (from-to)2093-2103
Number of pages11
JournalBlood
Volume73
Issue number8
StatePublished - Jan 1 1989

Fingerprint

Colony-Stimulating Factors
Alkylating Agents
Stem Cells
Irradiation
Cytokines
Granulocyte-Macrophage Colony-Stimulating Factor
Ionizing Radiation
Femur
Cyclophosphamide
Leukocytes
Bone Marrow
Survival
Therapeutics
Recovery
Ionizing radiation
Dosimetry
Bone
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Talmadge, J. E., Tribble, H., Pennington, R., Bowersox, O., Schneider, M. A., Castelli, P., ... Abe, F. (1989). Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors. Blood, 73(8), 2093-2103.

Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors. / Talmadge, J. E.; Tribble, H.; Pennington, R.; Bowersox, O.; Schneider, M. A.; Castelli, P.; Black, P. L.; Abe, F.

In: Blood, Vol. 73, No. 8, 01.01.1989, p. 2093-2103.

Research output: Contribution to journalArticle

Talmadge, JE, Tribble, H, Pennington, R, Bowersox, O, Schneider, MA, Castelli, P, Black, PL & Abe, F 1989, 'Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors', Blood, vol. 73, no. 8, pp. 2093-2103.
Talmadge JE, Tribble H, Pennington R, Bowersox O, Schneider MA, Castelli P et al. Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors. Blood. 1989 Jan 1;73(8):2093-2103.
Talmadge, J. E. ; Tribble, H. ; Pennington, R. ; Bowersox, O. ; Schneider, M. A. ; Castelli, P. ; Black, P. L. ; Abe, F. / Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors. In: Blood. 1989 ; Vol. 73, No. 8. pp. 2093-2103.
@article{2bc49a260d6a4b848cd4ac4c88fdfacd,
title = "Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors",
abstract = "Pretreatment of mice with recombinant murine (rM) colony-stimulating factor-granulocyte-macrophage (CSF-gm) or recombinant human (rH) CSF-g provides partial protection from the lethal effects of ionizing radiation or the alkylating agent cyclophosphamide (CTX). In addition, these agents can significantly prolong survival if administered following lethal doses of irradiation or CTX. To induce protective activity, cytokines were injected 20 hours before lethal irradiation or CTX administration. To accelerate recovery from lethal irradiation, the cytokines must be administered shortly following irradiation, and the induction of maximal levels of activity is dependent on chronic administration. In contrast, because of their longer half-lives, accelerated recovery from alkylating agents requires a delay of at least 24 to 48 hours to allow complete clearance of CTX before administration of a CSF. Studies quantitating peripheral blood leukocytes and bone marrow cellularity as well as colony-forming units per culture (CFU-C) frequency and CFU-C per femur revealed a significant correlation between these parameters and the ability to survive lethal irradiation.",
author = "Talmadge, {J. E.} and H. Tribble and R. Pennington and O. Bowersox and Schneider, {M. A.} and P. Castelli and Black, {P. L.} and F. Abe",
year = "1989",
month = "1",
day = "1",
language = "English (US)",
volume = "73",
pages = "2093--2103",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "8",

}

TY - JOUR

T1 - Protective, restorative, and therapeutic properties of recombinant colony-stimulating factors

AU - Talmadge, J. E.

AU - Tribble, H.

AU - Pennington, R.

AU - Bowersox, O.

AU - Schneider, M. A.

AU - Castelli, P.

AU - Black, P. L.

AU - Abe, F.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Pretreatment of mice with recombinant murine (rM) colony-stimulating factor-granulocyte-macrophage (CSF-gm) or recombinant human (rH) CSF-g provides partial protection from the lethal effects of ionizing radiation or the alkylating agent cyclophosphamide (CTX). In addition, these agents can significantly prolong survival if administered following lethal doses of irradiation or CTX. To induce protective activity, cytokines were injected 20 hours before lethal irradiation or CTX administration. To accelerate recovery from lethal irradiation, the cytokines must be administered shortly following irradiation, and the induction of maximal levels of activity is dependent on chronic administration. In contrast, because of their longer half-lives, accelerated recovery from alkylating agents requires a delay of at least 24 to 48 hours to allow complete clearance of CTX before administration of a CSF. Studies quantitating peripheral blood leukocytes and bone marrow cellularity as well as colony-forming units per culture (CFU-C) frequency and CFU-C per femur revealed a significant correlation between these parameters and the ability to survive lethal irradiation.

AB - Pretreatment of mice with recombinant murine (rM) colony-stimulating factor-granulocyte-macrophage (CSF-gm) or recombinant human (rH) CSF-g provides partial protection from the lethal effects of ionizing radiation or the alkylating agent cyclophosphamide (CTX). In addition, these agents can significantly prolong survival if administered following lethal doses of irradiation or CTX. To induce protective activity, cytokines were injected 20 hours before lethal irradiation or CTX administration. To accelerate recovery from lethal irradiation, the cytokines must be administered shortly following irradiation, and the induction of maximal levels of activity is dependent on chronic administration. In contrast, because of their longer half-lives, accelerated recovery from alkylating agents requires a delay of at least 24 to 48 hours to allow complete clearance of CTX before administration of a CSF. Studies quantitating peripheral blood leukocytes and bone marrow cellularity as well as colony-forming units per culture (CFU-C) frequency and CFU-C per femur revealed a significant correlation between these parameters and the ability to survive lethal irradiation.

UR - http://www.scopus.com/inward/record.url?scp=0024338814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024338814&partnerID=8YFLogxK

M3 - Article

C2 - 2471557

AN - SCOPUS:0024338814

VL - 73

SP - 2093

EP - 2103

JO - Blood

JF - Blood

SN - 0006-4971

IS - 8

ER -