Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration

Anil Kumar, Zhenqian Liu, Darlene Sheffer, Marilyn Smith, Dinesh K. Singh, Shilpa Buch, Opendra Narayan

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Using background data that live vaccines against several viral pathogens are effective in inducing life-long protection against disease, we undertook studies in macaques to determine the duration of protection that two live SHIV vaccines could induce against AIDS. Earlier studies had established that macaques immunized once with a live vaccine and challenged 6 months later were protected, and that other macaques given two sequential inoculations of live vaccines were protected for at least 1 year. Protection was associated with persistence of the vaccine viruses. In this study, we sought to determine whether the duration of protection in macaques given a single inoculation of replication competent live vaccines would extend beyond 3 years. Two groups of four rhesus macaques were inoculated with two live SHIV vaccines, respectively. The viruses replicated transiently in all animals but at the 3-year time point, PCR analysis of PBMC did not detect DNA of either virus in any of the animals, and all were negative for CMI responses in the blood. All 8 animals succumbed to disease when challenged with pathogenic viruses.

Original languageEnglish (US)
Pages (from-to)238-245
Number of pages8
JournalVirology
Volume371
Issue number2
DOIs
StatePublished - Feb 20 2008

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Attenuated Vaccines
Macaca
Acquired Immunodeficiency Syndrome
Vaccines
Viruses
DNA Viruses
Macaca mulatta
Polymerase Chain Reaction

Keywords

  • Attenuated virus
  • Challenge
  • Macaque
  • Protection
  • SHIV
  • SIV

ASJC Scopus subject areas

  • Virology

Cite this

Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration. / Kumar, Anil; Liu, Zhenqian; Sheffer, Darlene; Smith, Marilyn; Singh, Dinesh K.; Buch, Shilpa; Narayan, Opendra.

In: Virology, Vol. 371, No. 2, 20.02.2008, p. 238-245.

Research output: Contribution to journalArticle

Kumar, A, Liu, Z, Sheffer, D, Smith, M, Singh, DK, Buch, S & Narayan, O 2008, 'Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration', Virology, vol. 371, no. 2, pp. 238-245. https://doi.org/10.1016/j.virol.2007.10.008
Kumar, Anil ; Liu, Zhenqian ; Sheffer, Darlene ; Smith, Marilyn ; Singh, Dinesh K. ; Buch, Shilpa ; Narayan, Opendra. / Protection of macaques against AIDS with a live attenuated SHIV vaccine is of finite duration. In: Virology. 2008 ; Vol. 371, No. 2. pp. 238-245.
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