Protection by carbon tetrachloride against the toxic effects of dimethylnitrosamine in mice

A. W. Pound, T. A. Lawson

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A single intraperitoneal dose of carbon tetrachloride (CCl4), from 0.004 to 0.5 ml/kg, protected male mice against the toxic effects of dimethylnitrosamine (DMN). The LD50 of DMN was increased by a factor of about 4.2 with the highest dose of CCl4 and by a lesser factor with lower doses. The increase in LD50 correlated with a decrease in DMN demethylase activity in the liver of CCl4 treated mice. These effects commenced within 10 min of administration of CCl4 increased very rapidly for 12 hr to a high level which was maintained for up to 60 hr after which the LD50 of DMN and the level of DMN demethylase returned slowly to normal only in 5 or 6 days. The administration of CCl4 reduced the acute hepatonecrotic action of DMN.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalBritish Journal of Experimental Pathology
Issue number1
Publication statusPublished - Dec 1 1975


ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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