Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats

A. W. Pound, Terence A Lawson

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A single intragastric dose of carbon tetrachloride (CCl4) (0.01-2.5 ml/kg protected male Sprague Dawley rats against the toxic effects of dimethylnitrosamine (DMN). This appeared to be due to the reduction in the levels of DMN demethylase, a microsomal enzyme involved in the metabolism of DMN. The increase in the LD50 of DMN and the reduction in demethylase levels were observed within 20 min of dosing the CCl4. The changes were maximal by 12 hr, persisted until 48 hr and began to recover between 48 and 60 hr. The LD50 of DMN and the level of DMN demethylase returned to normal between 120 and 144 hr. Carbon tetrachloride also prevented the development of the hepatocellular necrosis which normally follows the administration of toxic doses of DMN.

Original languageEnglish (US)
Pages (from-to)203-212
Number of pages10
JournalBritish Journal of Experimental Pathology
Volume55
Issue number2
StatePublished - Dec 1 1974

Fingerprint

Dimethylnitrosamine
Carbon Tetrachloride
Poisons
Lethal Dose 50
Sprague Dawley Rats
Necrosis
Enzymes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats. / Pound, A. W.; Lawson, Terence A.

In: British Journal of Experimental Pathology, Vol. 55, No. 2, 01.12.1974, p. 203-212.

Research output: Contribution to journalArticle

@article{511f9b1ab08645c3b966e002511e5a9a,
title = "Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats",
abstract = "A single intragastric dose of carbon tetrachloride (CCl4) (0.01-2.5 ml/kg protected male Sprague Dawley rats against the toxic effects of dimethylnitrosamine (DMN). This appeared to be due to the reduction in the levels of DMN demethylase, a microsomal enzyme involved in the metabolism of DMN. The increase in the LD50 of DMN and the reduction in demethylase levels were observed within 20 min of dosing the CCl4. The changes were maximal by 12 hr, persisted until 48 hr and began to recover between 48 and 60 hr. The LD50 of DMN and the level of DMN demethylase returned to normal between 120 and 144 hr. Carbon tetrachloride also prevented the development of the hepatocellular necrosis which normally follows the administration of toxic doses of DMN.",
author = "Pound, {A. W.} and Lawson, {Terence A}",
year = "1974",
month = "12",
day = "1",
language = "English (US)",
volume = "55",
pages = "203--212",
journal = "International Journal of Experimental Pathology",
issn = "0959-9673",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats

AU - Pound, A. W.

AU - Lawson, Terence A

PY - 1974/12/1

Y1 - 1974/12/1

N2 - A single intragastric dose of carbon tetrachloride (CCl4) (0.01-2.5 ml/kg protected male Sprague Dawley rats against the toxic effects of dimethylnitrosamine (DMN). This appeared to be due to the reduction in the levels of DMN demethylase, a microsomal enzyme involved in the metabolism of DMN. The increase in the LD50 of DMN and the reduction in demethylase levels were observed within 20 min of dosing the CCl4. The changes were maximal by 12 hr, persisted until 48 hr and began to recover between 48 and 60 hr. The LD50 of DMN and the level of DMN demethylase returned to normal between 120 and 144 hr. Carbon tetrachloride also prevented the development of the hepatocellular necrosis which normally follows the administration of toxic doses of DMN.

AB - A single intragastric dose of carbon tetrachloride (CCl4) (0.01-2.5 ml/kg protected male Sprague Dawley rats against the toxic effects of dimethylnitrosamine (DMN). This appeared to be due to the reduction in the levels of DMN demethylase, a microsomal enzyme involved in the metabolism of DMN. The increase in the LD50 of DMN and the reduction in demethylase levels were observed within 20 min of dosing the CCl4. The changes were maximal by 12 hr, persisted until 48 hr and began to recover between 48 and 60 hr. The LD50 of DMN and the level of DMN demethylase returned to normal between 120 and 144 hr. Carbon tetrachloride also prevented the development of the hepatocellular necrosis which normally follows the administration of toxic doses of DMN.

UR - http://www.scopus.com/inward/record.url?scp=0016230991&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016230991&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 203

EP - 212

JO - International Journal of Experimental Pathology

JF - International Journal of Experimental Pathology

SN - 0959-9673

IS - 2

ER -