Prostate motion and isocenter adjustment from ultrasound-based localization during delivery of radiation therapy

Albert Y C Fung, Charles Arthur Enke, Komanduri M. Ayyangar, Natarajan V. Raman, Weining Zhen, Robert Bruce Thompson, Sicong Li, Ramasamy M. Nehru, Sushakumari Pillai

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Purpose: To study prostate motion from 4,154 ultrasound alignment fractions on 130 prostate patients treated with conformal radiotherapy or intensity-modulated radiation therapy at the University of Nebraska Medical Center. Methods and Materials: Each prostate patient was immobilized in a vacuum cradle. Daily treatment was verified by ultrasound scan after laser setup with skin marks and before radiation delivery by the same physician responsible for anatomic delineation during planning. Directional statistics were employed to test the significance of shift directions. Results: Polar histograms showed the prevalence of prostate motion in superior-posterior directions. The average direction was about 27° from the superior axis. The average changes of prostate position in superior to inferior (SI), anterior-posterior (AP), and left to right (LR) directions and in radial distance were 0.25, -0.13, 0.03, and 0.92, cm respectively. Our data indicated that prostate motion was not patient specific, and its average magnitude remained virtually unchanged over time. Recommended planning target volume (PTV) margins for use without ultrasound localization were 0.90 cm in SI, 1.02 cm in AP, and 0.80 cm in LR directions. Conclusion: Ultrasound localization revealed a predominance of prostate shift from planning position in the superior-posterior direction, with an average closer to the superior axis. The motion data provides recommended margins for PTV.

Original languageEnglish (US)
Pages (from-to)984-992
Number of pages9
JournalInternational Journal of Radiation Oncology Biology Physics
Volume61
Issue number4
DOIs
StatePublished - Mar 15 2005

Fingerprint

Prostate
radiation therapy
delivery
Radiotherapy
adjusting
planning
margins
physicians
delineation
Conformal Radiotherapy
shift
histograms
Vacuum
Direction compound
alignment
statistics
Lasers
vacuum
Radiation
Physicians

Keywords

  • Adjuvant
  • Isocenter
  • Localization
  • Motion
  • Prostate
  • Ultrasound

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Prostate motion and isocenter adjustment from ultrasound-based localization during delivery of radiation therapy. / Fung, Albert Y C; Enke, Charles Arthur; Ayyangar, Komanduri M.; Raman, Natarajan V.; Zhen, Weining; Thompson, Robert Bruce; Li, Sicong; Nehru, Ramasamy M.; Pillai, Sushakumari.

In: International Journal of Radiation Oncology Biology Physics, Vol. 61, No. 4, 15.03.2005, p. 984-992.

Research output: Contribution to journalArticle

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