Interfraktionelle Bewegung der Prostataloge anhand von RTOG-Definitionen und täglichen CT-„on-Rails“: Unterscheidet sich die Zielbewegung der superioren und inferioren Anteile des klinischen Zielvolumens?

Translated title of the contribution: Prostate bed target interfractional motion using RTOG consensus definitions and daily CT on rails: Does target motion differ between superior and inferior portions of the clinical target volume?

Vivek Verma, Shifeng Chen, Sumin Zhou, Charles Arthur Enke, Andrew O Wahl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Purpose: Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differed from the inferior PB-CTV (INF-CTV). Patients and methods: Eight pT2-3bN0-1M0 patients underwent postprostatectomy intensity-modulated radiotherapy, totaling 300 fractions. INF-CTV and SUP-CTV were defined as PB-CTV located inferior and superior to the superior border of the pubic symphysis, respectively. Daily pretreatment CT-on-rails images were compared to the planning CT in the left–right (LR), superoinferior (SI), and anteroposterior (AP) directions. Two parameters were defined: “total PB-CTV motion” represented total shifts from skin tattoos to RTOG-defined anatomic areas; “PB-CTV target motion” (performed for both SUP-CTV and INF-CTV) represented shifts from bone to RTOG-defined anatomic areas (i. e., subtracting shifts from skin tattoos to bone). Results: Mean (± standard deviation, SD) total PB-CTV motion was −1.5 (± 6.0), 1.3 (± 4.5), and 3.7 (± 5.7) mm in LR, SI, and AP directions, respectively. Mean (± SD) PB-CTV target motion was 0.2 (±1.4), 0.3 (±2.4), and 0 (±3.1) mm in the LR, SI, and AP directions, respectively. Mean (± SD) INF-CTV target motion was 0.1 (± 2.8), 0.5 (± 2.2), and 0.2 (± 2.5) mm, and SUP-CTV target motion was 0.3 (± 1.8), 0.5 (± 2.3), and 0 (± 5.0) mm in LR, SI, and AP directions, respectively. No statistically significant differences between INF-CTV and SUP-CTV motion were present in any direction. Conclusion: There are no statistically apparent motion differences between SUP-CTV and INF-CTV. Current uniform planning target volume (PTV) margins are adequate to cover both portions of the CTV.

Original languageGerman
Pages (from-to)38-45
Number of pages8
JournalStrahlentherapie und Onkologie
Volume193
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Radiation Oncology
Prostate
Radiotherapy
Pubic Symphysis
Bone and Bones
Intensity-Modulated Radiotherapy
Skin
Surgical Instruments
Direction compound

Keywords

  • Computed tomography
  • Prostate cancer
  • Prostatectomy
  • Radiotherapy, intensity modulated
  • Toxicity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

@article{50e291f062544082bddaa210928835e4,
title = "Interfraktionelle Bewegung der Prostataloge anhand von RTOG-Definitionen und t{\"a}glichen CT-„on-Rails“: Unterscheidet sich die Zielbewegung der superioren und inferioren Anteile des klinischen Zielvolumens?",
abstract = "Purpose: Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differed from the inferior PB-CTV (INF-CTV). Patients and methods: Eight pT2-3bN0-1M0 patients underwent postprostatectomy intensity-modulated radiotherapy, totaling 300 fractions. INF-CTV and SUP-CTV were defined as PB-CTV located inferior and superior to the superior border of the pubic symphysis, respectively. Daily pretreatment CT-on-rails images were compared to the planning CT in the left–right (LR), superoinferior (SI), and anteroposterior (AP) directions. Two parameters were defined: “total PB-CTV motion” represented total shifts from skin tattoos to RTOG-defined anatomic areas; “PB-CTV target motion” (performed for both SUP-CTV and INF-CTV) represented shifts from bone to RTOG-defined anatomic areas (i. e., subtracting shifts from skin tattoos to bone). Results: Mean (± standard deviation, SD) total PB-CTV motion was −1.5 (± 6.0), 1.3 (± 4.5), and 3.7 (± 5.7) mm in LR, SI, and AP directions, respectively. Mean (± SD) PB-CTV target motion was 0.2 (±1.4), 0.3 (±2.4), and 0 (±3.1) mm in the LR, SI, and AP directions, respectively. Mean (± SD) INF-CTV target motion was 0.1 (± 2.8), 0.5 (± 2.2), and 0.2 (± 2.5) mm, and SUP-CTV target motion was 0.3 (± 1.8), 0.5 (± 2.3), and 0 (± 5.0) mm in LR, SI, and AP directions, respectively. No statistically significant differences between INF-CTV and SUP-CTV motion were present in any direction. Conclusion: There are no statistically apparent motion differences between SUP-CTV and INF-CTV. Current uniform planning target volume (PTV) margins are adequate to cover both portions of the CTV.",
keywords = "Computed tomography, Prostate cancer, Prostatectomy, Radiotherapy, intensity modulated, Toxicity",
author = "Vivek Verma and Shifeng Chen and Sumin Zhou and Enke, {Charles Arthur} and Wahl, {Andrew O}",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/s00066-016-1077-6",
language = "German",
volume = "193",
pages = "38--45",
journal = "Strahlentherapie und Onkologie",
issn = "0179-7158",
publisher = "Urban und Vogel",
number = "1",

}

TY - JOUR

T1 - Interfraktionelle Bewegung der Prostataloge anhand von RTOG-Definitionen und täglichen CT-„on-Rails“

T2 - Unterscheidet sich die Zielbewegung der superioren und inferioren Anteile des klinischen Zielvolumens?

AU - Verma, Vivek

AU - Chen, Shifeng

AU - Zhou, Sumin

AU - Enke, Charles Arthur

AU - Wahl, Andrew O

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Purpose: Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differed from the inferior PB-CTV (INF-CTV). Patients and methods: Eight pT2-3bN0-1M0 patients underwent postprostatectomy intensity-modulated radiotherapy, totaling 300 fractions. INF-CTV and SUP-CTV were defined as PB-CTV located inferior and superior to the superior border of the pubic symphysis, respectively. Daily pretreatment CT-on-rails images were compared to the planning CT in the left–right (LR), superoinferior (SI), and anteroposterior (AP) directions. Two parameters were defined: “total PB-CTV motion” represented total shifts from skin tattoos to RTOG-defined anatomic areas; “PB-CTV target motion” (performed for both SUP-CTV and INF-CTV) represented shifts from bone to RTOG-defined anatomic areas (i. e., subtracting shifts from skin tattoos to bone). Results: Mean (± standard deviation, SD) total PB-CTV motion was −1.5 (± 6.0), 1.3 (± 4.5), and 3.7 (± 5.7) mm in LR, SI, and AP directions, respectively. Mean (± SD) PB-CTV target motion was 0.2 (±1.4), 0.3 (±2.4), and 0 (±3.1) mm in the LR, SI, and AP directions, respectively. Mean (± SD) INF-CTV target motion was 0.1 (± 2.8), 0.5 (± 2.2), and 0.2 (± 2.5) mm, and SUP-CTV target motion was 0.3 (± 1.8), 0.5 (± 2.3), and 0 (± 5.0) mm in LR, SI, and AP directions, respectively. No statistically significant differences between INF-CTV and SUP-CTV motion were present in any direction. Conclusion: There are no statistically apparent motion differences between SUP-CTV and INF-CTV. Current uniform planning target volume (PTV) margins are adequate to cover both portions of the CTV.

AB - Purpose: Using high-quality CT-on-rails imaging, the daily motion of the prostate bed clinical target volume (PB-CTV) based on consensus Radiation Therapy Oncology Group (RTOG) definitions (instead of surgical clips/fiducials) was studied. It was assessed whether PB motion in the superior portion of PB-CTV (SUP-CTV) differed from the inferior PB-CTV (INF-CTV). Patients and methods: Eight pT2-3bN0-1M0 patients underwent postprostatectomy intensity-modulated radiotherapy, totaling 300 fractions. INF-CTV and SUP-CTV were defined as PB-CTV located inferior and superior to the superior border of the pubic symphysis, respectively. Daily pretreatment CT-on-rails images were compared to the planning CT in the left–right (LR), superoinferior (SI), and anteroposterior (AP) directions. Two parameters were defined: “total PB-CTV motion” represented total shifts from skin tattoos to RTOG-defined anatomic areas; “PB-CTV target motion” (performed for both SUP-CTV and INF-CTV) represented shifts from bone to RTOG-defined anatomic areas (i. e., subtracting shifts from skin tattoos to bone). Results: Mean (± standard deviation, SD) total PB-CTV motion was −1.5 (± 6.0), 1.3 (± 4.5), and 3.7 (± 5.7) mm in LR, SI, and AP directions, respectively. Mean (± SD) PB-CTV target motion was 0.2 (±1.4), 0.3 (±2.4), and 0 (±3.1) mm in the LR, SI, and AP directions, respectively. Mean (± SD) INF-CTV target motion was 0.1 (± 2.8), 0.5 (± 2.2), and 0.2 (± 2.5) mm, and SUP-CTV target motion was 0.3 (± 1.8), 0.5 (± 2.3), and 0 (± 5.0) mm in LR, SI, and AP directions, respectively. No statistically significant differences between INF-CTV and SUP-CTV motion were present in any direction. Conclusion: There are no statistically apparent motion differences between SUP-CTV and INF-CTV. Current uniform planning target volume (PTV) margins are adequate to cover both portions of the CTV.

KW - Computed tomography

KW - Prostate cancer

KW - Prostatectomy

KW - Radiotherapy, intensity modulated

KW - Toxicity

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