Prostaglandin-induced iris color darkening: An experimental model

Gui Lin Zhan, Carol B Toris, Carl B. Camras, Yun Liang Wang, Laszlo Z. Bito

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Objectives: To determine the role of sympathetic innervation and the effect of topical prostaglandin therapy on iris color in pigmented rabbits. Methods: Twelve Dutch-belted rabbits underwent unilateral superior cervical ganglionectomy (SCGx) at age 1 to 3 months. A second group of 11 rabbits underwent bilateral SCGx at age 1 month and were treated once or twice daily for 6 to 9 months with 1 drop (about 20 μL) of latanoprost, 0.005%, to one eye and its vehicle to the contralateral eye. Standardized color photographs of the iris of each eye were taken at 1- to 2-month intervals for 6 to 10 months and evaluated by 4 to 6 observers in a masked fashion. Results: At 8 to 10 months after unilateral SCGx, 11 of 12 rabbits showed definite heterochromia, with the lighter-colored iris on the SCGx side. Of the 11 rabbits that underwent bilateral SCGx and unilateral latanoprost treatment, 9 showed heterochromia at 6 to 9 months, with the darker-colored iris on the latanoprost-treated side. Conclusions: These results demonstrate that sympathetic innervation is required for age-related, physiologic darkening of iris color in rabbits, that prostaglandins may compensate for sympathetic denervation to produce darkening in SCGx eyes, and that this model may be useful to study prostaglandin-induced iris color change.

Original languageEnglish (US)
Pages (from-to)1065-1068
Number of pages4
JournalArchives of Ophthalmology
Volume116
Issue number8
DOIs
StatePublished - Aug 1998

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latanoprost
Iris
Prostaglandins
Theoretical Models
Color
Rabbits
Ganglionectomy
Sympathectomy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Prostaglandin-induced iris color darkening : An experimental model. / Zhan, Gui Lin; Toris, Carol B; Camras, Carl B.; Wang, Yun Liang; Bito, Laszlo Z.

In: Archives of Ophthalmology, Vol. 116, No. 8, 08.1998, p. 1065-1068.

Research output: Contribution to journalArticle

Zhan, Gui Lin ; Toris, Carol B ; Camras, Carl B. ; Wang, Yun Liang ; Bito, Laszlo Z. / Prostaglandin-induced iris color darkening : An experimental model. In: Archives of Ophthalmology. 1998 ; Vol. 116, No. 8. pp. 1065-1068.
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abstract = "Objectives: To determine the role of sympathetic innervation and the effect of topical prostaglandin therapy on iris color in pigmented rabbits. Methods: Twelve Dutch-belted rabbits underwent unilateral superior cervical ganglionectomy (SCGx) at age 1 to 3 months. A second group of 11 rabbits underwent bilateral SCGx at age 1 month and were treated once or twice daily for 6 to 9 months with 1 drop (about 20 μL) of latanoprost, 0.005{\%}, to one eye and its vehicle to the contralateral eye. Standardized color photographs of the iris of each eye were taken at 1- to 2-month intervals for 6 to 10 months and evaluated by 4 to 6 observers in a masked fashion. Results: At 8 to 10 months after unilateral SCGx, 11 of 12 rabbits showed definite heterochromia, with the lighter-colored iris on the SCGx side. Of the 11 rabbits that underwent bilateral SCGx and unilateral latanoprost treatment, 9 showed heterochromia at 6 to 9 months, with the darker-colored iris on the latanoprost-treated side. Conclusions: These results demonstrate that sympathetic innervation is required for age-related, physiologic darkening of iris color in rabbits, that prostaglandins may compensate for sympathetic denervation to produce darkening in SCGx eyes, and that this model may be useful to study prostaglandin-induced iris color change.",
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